Liquid chromatography-tandem mass spectrometric assay for therapeutic drug monitoring of the B-Raf inhibitor encorafenib, the EGFR inhibitors afatinib, erlotinib and gefitinib and the O-desmethyl metabolites of erlotinib and gefitinib in human plasma.

Sparidans, Rolf W; Rosing, Hilde; Rood, Johannes J M; Schellens, Jan H M; Beijnen, Jos H

Sparidans, Rolf W; Rosing, Hilde; Rood, Johannes J M; Schellens, Jan H M; Beijnen, Jos H.

Afiliação

Sparidans RW; Utrecht University, Faculty of Science, Department of Pharmaceutical Sciences, Division of Pharmacoepidemiology & Clinical Pharmacology, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands; Utrecht University, Faculty of Science, Department of Pharmaceutical Sciences, Division of Chemical Biol
Rosing H; MC Slotervaart, Department of Pharmacy & Pharmacology, Louwesweg 6, 1066 EC Amsterdam, The Netherlands. Electronic address: H.Rosing@nki.nl.
Rood JJM; Utrecht University, Faculty of Science, Department of Pharmaceutical Sciences, Division of Pharmacoepidemiology & Clinical Pharmacology, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands. Electronic address: J.J.M.Rood@uu.nl.
Schellens JHM; Utrecht University, Faculty of Science, Department of Pharmaceutical Sciences, Division of Pharmacoepidemiology & Clinical Pharmacology, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands; The Netherlands Cancer Institute, Department of Clinical Pharmacology, Plesmanlaan 121, 1066 CX Amsterda
Beijnen JH; Utrecht University, Faculty of Science, Department of Pharmaceutical Sciences, Division of Pharmacoepidemiology & Clinical Pharmacology, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands; MC Slotervaart, Department of Pharmacy & Pharmacology, Louwesweg 6, 1066 EC Amsterdam, The Netherlan

J Chromatogr B Analyt Technol Biomed Life Sci ; 1033-1034: 390-398, 2016 Oct 15.

Article em En | MEDLINE | ID: mdl-27639128

Assuntos

Carbamatos/análise; Cromatografia Líquida/métodos; Monitoramento de Medicamentos; Cloridrato de Erlotinib/sangue; Quinazolinas/análise; Quinazolinas/sangue; Sulfonamidas/análise; Espectrometria de Massas em Tandem/métodos; Administração Oral; Adulto; Afatinib; Idoso; Idoso de 80 Anos ou mais; Calibragem; Carbamatos/química; Receptores ErbB/antagonistas & inibidores; Receptores ErbB/metabolismo; Cloridrato de Erlotinib/química; Feminino; Gefitinibe; Humanos; Masculino; Pessoa de Meia-Idade; Inibidores de Proteínas Quinases/análise; Inibidores de Proteínas Quinases/farmacologia; Proteínas Proto-Oncogênicas B-raf/antagonistas & inibidores; Proteínas Proto-Oncogênicas B-raf/metabolismo; Quinazolinas/química; Reprodutibilidade dos Testes; Sulfonamidas/química

Palavras-chave

Afatinib; Encorafenib; Erlotinib; Gefitinib; LCMS/MS; Plasma

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinazolinas / Sulfonamidas / Carbamatos / Cromatografia Líquida / Monitoramento de Medicamentos / Espectrometria de Massas em Tandem / Cloridrato de Erlotinib Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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