Transient receptor potential channel 1/4 reduces subarachnoid hemorrhage-induced early brain injury in rats via calcineurin-mediated NMDAR and NFAT dephosphorylation.

Wang, Zhong; Wang, Yibin; Tian, Xiaodi; Shen, Haitao; Dou, Yang; Li, Haiying; Chen, Gang

Wang, Zhong; Wang, Yibin; Tian, Xiaodi; Shen, Haitao; Dou, Yang; Li, Haiying; Chen, Gang.

Afiliação

Wang Z; Department of Neurosurgery &Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou 215006, China.
Wang Y; Department of Neurosurgery &Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou 215006, China.
Tian X; Department of Neurosurgery &Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou 215006, China.
Shen H; Department of Neurosurgery &Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou 215006, China.
Dou Y; Department of Neurosurgery &Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou 215006, China.
Li H; Department of Neurosurgery &Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou 215006, China.
Chen G; Department of Neurosurgery &Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou 215006, China.

Sci Rep ; 6: 33577, 2016 09 19.

Article em En | MEDLINE | ID: mdl-27641617

Assuntos

Hemorragia Encefálica Traumática/metabolismo; Calcineurina/metabolismo; Fatores de Transcrição NFATC/metabolismo; Receptores de N-Metil-D-Aspartato/metabolismo; Canais de Cátion TRPC/metabolismo; Transporte Ativo do Núcleo Celular; Animais; Biomarcadores; Hemorragia Encefálica Traumática/tratamento farmacológico; Hemorragia Encefálica Traumática/patologia; Morte Celular/efeitos dos fármacos; Modelos Biológicos; Neurônios/efeitos dos fármacos; Neurônios/metabolismo; Oxiemoglobinas/metabolismo; Oxiemoglobinas/farmacologia; Fosforilação; Ratos; Hemorragia Subaracnóidea; Canais de Cátion TRPC/antagonistas & inibidores

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de N-Metil-D-Aspartato / Calcineurina / Hemorragia Encefálica Traumática / Canais de Cátion TRPC / Fatores de Transcrição NFATC Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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