Subchronic Arsenic Exposure Through Drinking Water Alters Lipid Profile and Electrolyte Status in Rats.
Biol Trace Elem Res
; 176(2): 350-354, 2017 Apr.
Article
em En
| MEDLINE
| ID: mdl-27646559
ABSTRACT
Arsenic is a groundwater pollutant and can cause various cardiovascular disorders in the exposed population. The aim of the present study was to assess whether subchronic arsenic exposure through drinking water can induce vascular dysfunction associated with alteration in plasma electrolytes and lipid profile. Rats were exposed to arsenic as 25, 50, and 100 ppm of sodium arsenite through drinking water for 90 consecutive days. On the 91st day, rats were sacrificed and blood was collected. Lipid profile and the levels of electrolytes (sodium, potassium, and chloride) were assessed in plasma. Arsenic reduced high-density lipoprotein cholesterol (HDL-C) and HDL-C/LDL-C ratio, but increased the levels of triglycerides, total cholesterol, low-density lipoprotein cholesterol (LDL-C), and electrolytes. The results suggest that the arsenic-mediated dyslipidemia and electrolyte retention could be important mechanisms in the arsenic-induced vascular disorder.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Potássio
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Sódio
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Água Potável
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Cloretos
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Compostos de Sódio
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Arsenitos
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Eletrólitos
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Lipídeos
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article