Bromodomain and Extraterminal Protein Inhibition Blocks Growth of Triple-negative Breast Cancers through the Suppression of Aurora Kinases.

Sahni, Jennifer M; Gayle, Sylvia S; Bonk, Kristen L Weber; Vite, Leslie Cuellar; Yori, Jennifer L; Webb, Bryan; Ramos, Erika K; Seachrist, Darcie D; Landis, Melissa D; Chang, Jenny C; Bradner, James E; Keri, Ruth A

Sahni, Jennifer M; Gayle, Sylvia S; Bonk, Kristen L Weber; Vite, Leslie Cuellar; Yori, Jennifer L; Webb, Bryan; Ramos, Erika K; Seachrist, Darcie D; Landis, Melissa D; Chang, Jenny C; Bradner, James E; Keri, Ruth A.

Afiliação

Sahni JM; From the Departments of Pharmacology and.
Gayle SS; From the Departments of Pharmacology and.
Bonk KL; From the Departments of Pharmacology and.
Vite LC; From the Departments of Pharmacology and.
Yori JL; From the Departments of Pharmacology and.
Webb B; From the Departments of Pharmacology and.
Ramos EK; From the Departments of Pharmacology and.
Seachrist DD; From the Departments of Pharmacology and.
Landis MD; the Methodist Cancer Center, Houston Methodist Hospital, Houston, Texas 77030, and.
Chang JC; the Methodist Cancer Center, Houston Methodist Hospital, Houston, Texas 77030, and.
Bradner JE; the Dana-Farber Cancer Institute, Boston, Massachusetts 02115.
Keri RA; From the Departments of Pharmacology and keri@case.edu.

J Biol Chem ; 291(45): 23756-23768, 2016 Nov 04.

Article em En | MEDLINE | ID: mdl-27650498

Assuntos

Antineoplásicos/uso terapêutico; Aurora Quinase A/antagonistas & inibidores; Aurora Quinase B/antagonistas & inibidores; Mama/efeitos dos fármacos; Proteínas Nucleares/antagonistas & inibidores; Inibidores de Proteínas Quinases/uso terapêutico; Fatores de Transcrição/antagonistas & inibidores; Neoplasias de Mama Triplo Negativas/tratamento farmacológico; Animais; Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Aurora Quinase A/metabolismo; Aurora Quinase B/metabolismo; Mama/metabolismo; Mama/patologia; Proteínas de Ciclo Celular; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Feminino; Humanos; Camundongos; Camundongos Endogâmicos NOD; Camundongos SCID; Proteínas Nucleares/metabolismo; Inibidores de Proteínas Quinases/farmacologia; Fatores de Transcrição/metabolismo; Neoplasias de Mama Triplo Negativas/metabolismo; Neoplasias de Mama Triplo Negativas/patologia

Palavras-chave

Aurora kinase; anticancer drug; apoptosis; breast cancer; bromodomain-containing protein 4 (BRD4); cellular senescence; inhibition mechanism

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Mama / Proteínas Nucleares / Inibidores de Proteínas Quinases / Neoplasias de Mama Triplo Negativas / Aurora Quinase A / Aurora Quinase B / Antineoplásicos Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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