Effects of smoking status and MADRS retardation factor on response to low frequency repetitive transcranial magnetic stimulation for depression.
Eur Psychiatry
; 38: 40-44, 2016 10.
Article
em En
| MEDLINE
| ID: mdl-27657664
ABSTRACT
BACKGROUND:
Despite growing evidence supporting the clinical interest of repetitive transcranial magnetic stimulation (rTMS) in treatment-resistant depression (TRD), little is known regarding the effects of clinical and sociodemographic factors on the clinical outcome in patients.METHODS:
We retrospectively investigated the effects of clinical (using the 3-factor model of the Montgomery-Åsberg depression rating scale [MADRS] encompassing dysphoria, retardation and vegetative symptoms) and sociodemographic characteristics of participants on clinical outcome in a sample of 54 TRD patients receiving low frequency rTMS (1Hz, 360 pulses) applied over the right dorsolateral prefrontal cortex combined with sham venlafaxine.RESULTS:
Responders (n=29) displayed lower retardation baseline scores (13.6±2.9) than non-responders (15.6±2.9; n=25; P=0.02). We also observed a significant difference between the numbers of ex-smokers in responders and non-responders groups; all ex-smokers (n=8) were responders to rTMS (P=0.005).CONCLUSION:
Low MADRS retardation factor and ex-smoker status is highly prevalent in responders to low frequency rTMS. Further studies are needed to investigate the predictive value of these factors.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Fumar
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Córtex Pré-Frontal
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Estimulação Magnética Transcraniana
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Transtorno Depressivo Resistente a Tratamento
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article