Immune and Pancreatic ß Cell Interactions in Type 1 Diabetes.
Trends Endocrinol Metab
; 27(12): 856-867, 2016 12.
Article
em En
| MEDLINE
| ID: mdl-27659143
ABSTRACT
The autoimmune destruction of the pancreatic islet ß cells is due to a targeted lymphocyte attack. Different T cell subsets communicate with each other and with the insulin-producing ß cells in this process, with evidence not only of damage to the tissue cells but also of lymphocyte regulation. Here we explore the various components of the immune response as well as the cellular interactions that are involved in causing or reducing immune damage to the ß cells. We consider these in the light of the possibility that understanding them may help us identify therapeutic targets to reduce the damage and destruction leading to type 1 diabetes.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
/
Diabetes Mellitus Tipo 1
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Células Secretoras de Insulina
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article