Mechanism and Regulation of NLRP3 Inflammasome Activation.
Trends Biochem Sci
; 41(12): 1012-1021, 2016 12.
Article
em En
| MEDLINE
| ID: mdl-27669650
ABSTRACT
Members of the nucleotide-binding domain and leucine-rich repeat (LRR)-containing (NLR) family and the pyrin and HIN domain (PYHIN) family can form multiprotein complexes termed 'inflammasomes'. The biochemical function of inflammasomes is to activate caspase-1, which leads to the maturation of interleukin 1 beta (IL-1ß) and IL-18 and the induction of pyroptosis, a form of cell death. Unlike other inflammasomes, the NLRP3 inflammasome can be activated by diverse stimuli. The importance of the NLRP3 inflammasome in immunity and human diseases has been well documented, but the mechanism and regulation of its activation remain unclear. In this review we summarize current understanding of the mechanism and regulation of NLRP3 inflammasome activation as well as recent advances in the noncanonical and alternative inflammasome pathways.
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Base de dados:
MEDLINE
Assunto principal:
Caspase 1
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Inflamassomos
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Piroptose
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Proteína 3 que Contém Domínio de Pirina da Família NLR
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Macrófagos
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article