BET protein bromodomain inhibitor-based combinations are highly active against post-myeloproliferative neoplasm secondary AML cells.

Saenz, Dyana T; Fiskus, Warren; Manshouri, Taghi; Rajapakshe, Kimal; Krieger, Stephanie; Sun, Baohua; Mill, Christopher P; DiNardo, Courtney; Pemmaraju, Naveen; Kadia, Tapan; Parmar, Simrit; Sharma, Sunil; Coarfa, Cristian; Qiu, Peng; Verstovsek, Srdan; Bhalla, Kapil N

Saenz, Dyana T; Fiskus, Warren; Manshouri, Taghi; Rajapakshe, Kimal; Krieger, Stephanie; Sun, Baohua; Mill, Christopher P; DiNardo, Courtney; Pemmaraju, Naveen; Kadia, Tapan; Parmar, Simrit; Sharma, Sunil; Coarfa, Cristian; Qiu, Peng; Verstovsek, Srdan; Bhalla, Kapil N.

Afiliação

Saenz DT; Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston TX, 77030.
Fiskus W; Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston TX, 77030.
Manshouri T; Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston TX, 77030.
Rajapakshe K; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, 77030.
Krieger S; Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston TX, 77030.
Sun B; Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston TX, 77030.
Mill CP; Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston TX, 77030.
DiNardo C; Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston TX, 77030.
Pemmaraju N; Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston TX, 77030.
Kadia T; Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston TX, 77030.
Parmar S; Department of Stem Cell Transplantation, The University of Texas M.D. Anderson Cancer Center, Houston TX, 77030.
Sharma S; Center for Investigational Therapeutics, Huntsman Cancer Institute, Salt Lake City, UT 84112.
Coarfa C; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, 77030.
Qiu P; Department of Biomedical Engineering, Georgia Tech and Emory University, Atlanta, 30332.
Verstovsek S; Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston TX, 77030.
Bhalla KN; Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston TX, 77030.

Leukemia ; 31(3): 678-687, 2017 03.

Article em En | MEDLINE | ID: mdl-27677740

Assuntos

Antineoplásicos/farmacologia; Leucemia Mieloide Aguda/etiologia; Leucemia Mieloide Aguda/metabolismo; Transtornos Mieloproliferativos/complicações; Domínios e Motivos de Interação entre Proteínas/efeitos dos fármacos; Inibidores de Proteínas Quinases/farmacologia; Proteínas de Ligação a RNA/antagonistas & inibidores; Animais; Apoptose/efeitos dos fármacos; Apoptose/genética; Biomarcadores; Caspases/metabolismo; Linhagem Celular Tumoral; Modelos Animais de Doenças; Sinergismo Farmacológico; Genes myc; Sequenciamento de Nucleotídeos em Larga Escala; Humanos; Janus Quinase 2/antagonistas & inibidores; Janus Quinase 2/genética; Janus Quinase 2/metabolismo; Leucemia Mieloide Aguda/tratamento farmacológico; Leucemia Mieloide Aguda/patologia; Camundongos; Domínios e Motivos de Interação entre Proteínas/genética; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Proteínas de Ligação a RNA/química; Proteínas de Ligação a RNA/genética; Receptores de Interleucina-7/metabolismo; Fator de Transcrição STAT5/metabolismo; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Proteínas de Ligação a RNA / Inibidores de Proteínas Quinases / Domínios e Motivos de Interação entre Proteínas / Transtornos Mieloproliferativos / Antineoplásicos Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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