Your browser doesn't support javascript.
loading
Considering sex as a biological variable in preclinical research.
Miller, Leah R; Marks, Cheryl; Becker, Jill B; Hurn, Patricia D; Chen, Wei-Jung; Woodruff, Teresa; McCarthy, Margaret M; Sohrabji, Farida; Schiebinger, Londa; Wetherington, Cora Lee; Makris, Susan; Arnold, Arthur P; Einstein, Gillian; Miller, Virginia M; Sandberg, Kathryn; Maier, Susan; Cornelison, Terri L; Clayton, Janine A.
Afiliação
  • Miller LR; Office of Research on Women's Health, National Institutes of Health, Bethesda, Maryland, USA; leah.miller@nih.gov.
  • Marks C; Division of Cancer Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
  • Becker JB; Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan, USA.
  • Hurn PD; School of Nursing, University of Michigan, Ann Arbor, Michigan, USA.
  • Chen WJ; Department of Neuroscience and Experimental Therapeutics, Texas A&M Health Science Center, Bryan, Texas, USA.
  • Woodruff T; Women's Health Research Institute, Northwestern University, Chicago, Illinois, USA.
  • McCarthy MM; Department of Pharmacology, University of Maryland, Baltimore, Maryland, USA.
  • Sohrabji F; Department of Neuroscience and Experimental Therapeutics, Texas A&M Health Science Center, Bryan, Texas, USA.
  • Schiebinger L; History of Science, Stanford University, Stanford, California, USA.
  • Wetherington CL; National Institute on Drug Abuse, National Institutes of Health, Bethesda, Maryland, USA.
  • Makris S; Office of Research and Development, National Center for Environmental Assessment, U.S. Environmental Protection Agency, Washington, D.C., USA.
  • Arnold AP; Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California, USA.
  • Einstein G; Laboratory of Neuroendocrinology of the Brain Research Institute, University of California, Los Angeles, Los Angeles, California, USA.
  • Miller VM; Department of Psychology, University of Toronto, Toronto, Ontario, Canada.
  • Sandberg K; The Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
  • Maier S; Women's College Research Institute, Toronto, Ontario, Canada.
  • Cornelison TL; Department of Surgery and Physiology, Mayo Clinic, Rochester, Minnesota, USA.
  • Clayton JA; Department of Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.
FASEB J ; 31(1): 29-34, 2017 01.
Article em En | MEDLINE | ID: mdl-27682203
In June 2015, the National Institutes of Health (NIH) released a Guide notice (NOT-OD-15-102) that highlighted the expectation of the NIH that the possible role of sex as a biologic variable be factored into research design, analyses, and reporting of vertebrate animal and human studies. Anticipating these guidelines, the NIH Office of Research on Women's Health, in October 2014, convened key stakeholders to discuss methods and techniques for integrating sex as a biologic variable in preclinical research. The workshop focused on practical methods, experimental design, and approaches to statistical analyses in the use of both male and female animals, cells, and tissues in preclinical research. Workshop participants also considered gender as a modifier of biology. This article builds on the workshop and is meant as a guide to preclinical investigators as they consider methods and techniques for inclusion of both sexes in preclinical research and is not intended to prescribe exhaustive/specific approaches for compliance with the new NIH policy.-Miller, L. R., Marks, C., Becker, J. B., Hurn, P. D., Chen, W.-J., Woodruff, T., McCarthy, M. M., Sohrabji, F., Schiebinger, L., Wetherington, C. L., Makris, S., Arnold, A. P., Einstein, G., Miller, V. M., Sandberg, K., Maier, S., Cornelison, T. L., Clayton, J. A. Considering sex as a biological variable in preclinical research.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pesquisa Biomédica / Avaliação Pré-Clínica de Medicamentos / National Institutes of Health (U.S.) Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pesquisa Biomédica / Avaliação Pré-Clínica de Medicamentos / National Institutes of Health (U.S.) Idioma: En Ano de publicação: 2017 Tipo de documento: Article