Synthesis and antiproliferative activity of peracetylated 2-amino-1,2-dideoxy-1-nitro-d-glycero-l-manno and d-glycero-d-talo heptitols.
Bioorg Chem
; 69: 71-76, 2016 12.
Article
em En
| MEDLINE
| ID: mdl-27693943
ABSTRACT
Michael additions between carbohydrate derived nitroalkenes and several aliphatic and aromatic amines proceeded in a stereoselective way, leading to peracetylated 2-amino-1,2-dideoxy-1-nitro-heptitols. In addition, the antiproliferative activity of some of the new adducts has been studied. The results allowed to identify lead compounds which show GI50 values in the range 1.7-19µM.
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MEDLINE
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Açúcares Ácidos
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Antineoplásicos
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En
Ano de publicação:
2016
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Article