In vitro evaluation of apoptotic effect of bis(acetylacetonato-k2 O,O')(1,10-phenanthroline-k2 N,N')Zn(II) complex.
Chem Biol Drug Des
; 89(4): 529-537, 2017 04.
Article
em En
| MEDLINE
| ID: mdl-27696716
ABSTRACT
Phenanthroline derivatives have been reported as potential bioactive compounds because of their ability to interact with DNA. To evaluate the antiproliferative effect of bis(acetylacetonate-k2 O,O)(1,10-phenanthroline-k2 N,N)Zn(II) or Zn(acac)2 (phen) complex, the compound was obtained in a simple manner and further characterized to determine crystal structure, thermal behavior, morphology, and spectroscopic properties. The structure of the complex was confirmed by X-ray single structure as well as by 1H and 13C nuclear magnetic resonance (NMR) in dmso-d6 (dimethyl sulfoxide) solution and in the solid state by 13C CP/MAS. Although preparation of this compound has been described previously, there are no reports on its biological activity; here, we assessed its antiproliferative effect on fibroblasts, A253, FaDu, Cal-27, RH-30, RD, U-373, C6, A-549, MDA-MB-231, and MCF-7 cancer cell lines at different doses (50-100 and 150 µg/ml). The cell viability was determined by MTT assay and high activity was observed for the most of the cell lines, and TUNEL results showed the induction of apoptosis.
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Base de dados:
MEDLINE
Assunto principal:
Fenantrolinas
/
Zinco
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Apoptose
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article