Visualizing the Architectures and Interactions of Nuclear Receptors.
Endocrinology
; 157(11): 4212-4221, 2016 Nov.
Article
em En
| MEDLINE
| ID: mdl-27704949
ABSTRACT
Nuclear receptors (NRs) are master regulators of broad genetic programs in metazoans. These programs are regulated in part by the small-molecule ligands that bind NRs and modulate their interactions with transcriptional coregulatory factors. X-ray crystallography is now delivering more complete pictures of how the multidomain architectures of NR homo- and heterodimers are physically arranged on their DNA elements and how ligands and coactivator peptides act through these complexes. Complementary studies are also pointing to a variety of novel mechanisms by which NRs access their DNA-response elements within chromatin. Here, we review the new structural advances together with proteomic discoveries that shape our understanding of how NRs form a variety of functional interactions with collaborating factors in chromatin.
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1
Base de dados:
MEDLINE
Assunto principal:
Receptores Citoplasmáticos e Nucleares
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article