Stereocontrolled Syntheses of Seven-Membered Carbocycles by Tandem Allene Aziridination/[4+3] Reaction.
Angew Chem Int Ed Engl
; 55(42): 13240-13243, 2016 10 10.
Article
em En
| MEDLINE
| ID: mdl-27709816
ABSTRACT
A tandem allene aziridination/[4+3]/reduction sequence converts simple homoallenic sulfamates into densely functionalized aminated cycloheptenes, where the relative stereochemistry at five contiguous asymmetric centers can be controlled through the choice of the solvent and the reductant. The products resulting from this chemistry can be readily transformed into complex molecular scaffolds which contain up to seven contiguous stereocenters.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Aziridinas
/
Cicloeptanos
/
Alcenos
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article