Cytoplasmic aryl hydrocarbon receptor regulates glycogen synthase kinase 3 beta, accelerates vimentin degradation, and suppresses epithelial-mesenchymal transition in non-small cell lung cancer cells.

Li, Ching-Hao; Liu, Chen-Wei; Tsai, Chi-Hao; Peng, Yi-Jen; Yang, Yu-Hsuan; Liao, Po-Lin; Lee, Chen-Chen; Cheng, Yu-Wen; Kang, Jaw-Jou

Li, Ching-Hao; Liu, Chen-Wei; Tsai, Chi-Hao; Peng, Yi-Jen; Yang, Yu-Hsuan; Liao, Po-Lin; Lee, Chen-Chen; Cheng, Yu-Wen; Kang, Jaw-Jou.

Afiliação

Li CH; Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Liu CW; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Tsai CH; School of Pharmacy, Taipei Medicine University, 250 Wu-Hsing Street, Taipei, Taiwan.
Peng YJ; Institute of Toxicology, College of Medicine, National Taiwan University, 1 Jen-Ai Road, Section 1, Taipei 10, Taiwan.
Yang YH; Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Liao PL; Institute of Toxicology, College of Medicine, National Taiwan University, 1 Jen-Ai Road, Section 1, Taipei 10, Taiwan.
Lee CC; Institute of Toxicology, College of Medicine, National Taiwan University, 1 Jen-Ai Road, Section 1, Taipei 10, Taiwan.
Cheng YW; Department of Microbiology and Immunology, School of Medicine, China Medicine University, Taichung, Taiwan.
Kang JJ; School of Pharmacy, Taipei Medicine University, 250 Wu-Hsing Street, Taipei, Taiwan. ywcheng@tmu.edu.tw.

Arch Toxicol ; 91(5): 2165-2178, 2017 May.

Article em En | MEDLINE | ID: mdl-27752740

Assuntos

Carcinoma Pulmonar de Células não Pequenas/metabolismo; Glicogênio Sintase Quinase 3 beta/metabolismo; Neoplasias Pulmonares/metabolismo; Receptores de Hidrocarboneto Arílico/metabolismo; Vimentina/metabolismo; Idoso; Animais; Carcinoma Pulmonar de Células não Pequenas/patologia; Linhagem Celular Tumoral; Citoplasma/metabolismo; Transição Epitelial-Mesenquimal; Feminino; Humanos; Neoplasias Pulmonares/patologia; Masculino; Camundongos Endogâmicos C57BL; Pessoa de Meia-Idade; Complexo de Endopeptidases do Proteassoma/metabolismo; Receptores de Hidrocarboneto Arílico/genética; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

Aryl hydrocarbon receptor; Epithelialmesenchymal transition; Glycogen synthase kinase 3 beta; Ubiquitin; Vimentin

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vimentina / Receptores de Hidrocarboneto Arílico / Carcinoma Pulmonar de Células não Pequenas / Glicogênio Sintase Quinase 3 beta / Neoplasias Pulmonares Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google