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Neuroinflammatory and morphological changes in late-life depression: the NIMROD study.
Su, L; Faluyi, Y O; Hong, Y T; Fryer, T D; Mak, E; Gabel, S; Hayes, L; Soteriades, S; Williams, G B; Arnold, R; Passamonti, L; Rodríguez, P Vázquez; Surendranathan, A; Bevan-Jones, R W; Coles, J; Aigbirhio, F; Rowe, J B; O'Brien, J T.
Afiliação
  • Su L; Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, U
  • Faluyi YO; Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, U
  • Hong YT; Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, U
  • Fryer TD; Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, U
  • Mak E; Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, U
  • Gabel S; Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, U
  • Hayes L; Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, U
  • Soteriades S; Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, U
  • Williams GB; Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, U
  • Arnold R; Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, U
  • Passamonti L; Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, U
  • Rodríguez PV; Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, U
  • Surendranathan A; Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, U
  • Bevan-Jones RW; Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, U
  • Coles J; Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, U
  • Aigbirhio F; Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, U
  • Rowe JB; Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, U
  • O'Brien JT; Li Su, PhD, Yetunde O. Faluyi, MBChB, Department of Psychiatry, University of Cambridge, UK; Young T. Hong, PhD, Tim D. Fryer, PhD, Wolfson Brain Imaging Centre and Department of Clinical Neurosciences, University of Cambridge, UK; Elijah Mak, BA, Department of Psychiatry, University of Cambridge, U
Br J Psychiatry ; 209(6): 525-526, 2016 12.
Article em En | MEDLINE | ID: mdl-27758838
ABSTRACT
We studied neuroinflammation in individuals with late-life depression, as a risk factor for dementia, using [11C]PK11195 positron emission tomography (PET). Five older participants with major depression and 13 controls underwent PET and multimodal 3T magnetic resonance imaging (MRI), with blood taken to measure C-reactive protein (CRP). We found significantly higher CRP levels in those with late-life depression and raised [11C]PK11195 binding compared with controls in brain regions associated with depression, including subgenual anterior cingulate cortex, and significant hippocampal subfield atrophy in cornu ammonis 1 and subiculum. Our findings suggest neuroinflammation requires further investigation in late-life depression, both as a possible aetiological factor and a potential therapeutic target.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína C-Reativa / Córtex Cerebral / Receptores de GABA / Transtorno Depressivo Maior / Inflamação Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína C-Reativa / Córtex Cerebral / Receptores de GABA / Transtorno Depressivo Maior / Inflamação Idioma: En Ano de publicação: 2016 Tipo de documento: Article