Does one size fit all? The role of body mass index and waist circumference in systemic inflammation in midlife by race and gender.
Ethn Health
; 22(2): 169-183, 2017 04.
Article
em En
| MEDLINE
| ID: mdl-27774807
ABSTRACT
OBJECTIVE:
This study investigates the associations of body mass index (BMI) and waist circumference (WC) with markers of systemic inflammation in midlife by race and gender.DESIGN:
Data were obtained from the Survey of Midlife in the United States, a cross-sectional, observational study of Americans 35 years old or older (White men N = 410; White women N = 490; Black men N = 58; Black women N = 117). Inflammation was measured by concentrations of fibrinogen and C-reactive protein (CRP) in fasting plasma and concentrations of E-selectin and interleukin-6 (IL-6) in fasting serum. Anthropometric data were used to obtain BMI and WC. Socio-demographic and health-related factors were assessed with a survey. Multivariate models by race and gender were estimated to test the roles of BMI and WC for each inflammation marker.RESULTS:
Compared to White men, Black women have higher BMI and higher levels of all four inflammation markers; White women have lower BMI, lower WC, and lower E-selectin and fibrinogen but higher CRP; and Black men have higher fibrinogen. After adjusting for socio-demographic and health-related covariates as well as perceived discrimination, WC is associated with all four markers of inflammation among White men and women; with three markers (fibrinogen, CRP, and IL-6) of inflammation among Black women; and with CRP (and marginally with fibrinogen and E-selectin) among Black men. BMI is associated with higher CRP and fibrinogen among Black men (marginally so for White men) but not for women of either race.CONCLUSIONS:
WC shows more consistent associations with inflammation markers than BMI, although the relationships vary by inflammation marker and population group. Our findings suggest that WC is a risk factor for systemic inflammation among White and Black men and women, and BMI is an additional risk factor for Black men.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Negro ou Afro-Americano
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Índice de Massa Corporal
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População Branca
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Circunferência da Cintura
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Inflamação
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article