Prognostic significance of insulin-like growth factor-I serum levels in acute decompensation of cirrhosis.
Biomarkers
; 22(2): 127-132, 2017 Mar.
Article
em En
| MEDLINE
| ID: mdl-27775431
ABSTRACT
CONTEXT IGF-I serum levels are suppressed in cirrhosis, but its prognostic significance is unknown. OBJECTIVES:
To investigate the prognostic value of IGF-I in patients admitted for acute decompensation of cirrhosis. MATERIALS ANDMETHODS:
Cohort study that included 103 patients. IGF-I was measured by enzyme-linked immunosorbent assay (ELISA).RESULTS:
Ninety-day mortality was 26.2% and it was independently associated with MELD, age and IGF-I. The Kaplan-Meier survival probability at 90 days was 94.3% in patients with IGF-I ≥13 ng/mL and 63.2% for patients with IGF-I <13 ng/mL (p = .001). DISCUSSION ANDCONCLUSION:
IGF-I levels are independently associated with mortality in acute decompensation of cirrhosis.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fator de Crescimento Insulin-Like I
/
Cirrose Hepática
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article