Your browser doesn't support javascript.
loading
Lectin adhesion proteins (P-, L- and E-selectins) as biomarkers in colorectal cancer.
Korniluk, Aleksandra; Kaminska, Joanna; Kiszlo, Pawel; Kemona, Halina; Dymicka-Piekarska, Violetta.
Afiliação
  • Korniluk A; a Department of Clinical Laboratory Diagnostics , Medical University of Bialystok , Poland.
  • Kaminska J; a Department of Clinical Laboratory Diagnostics , Medical University of Bialystok , Poland.
  • Kiszlo P; a Department of Clinical Laboratory Diagnostics , Medical University of Bialystok , Poland.
  • Kemona H; a Department of Clinical Laboratory Diagnostics , Medical University of Bialystok , Poland.
  • Dymicka-Piekarska V; a Department of Clinical Laboratory Diagnostics , Medical University of Bialystok , Poland.
Biomarkers ; 22(7): 629-634, 2017 Nov.
Article em En | MEDLINE | ID: mdl-27775438
CONTEXT: Selectins probably participate in the interactions between platelets and other inflammatory cells in cancer invasion and metastasis formation. We assessed a potential relationship of P-, L- and E-selectin in colorectal cancer (CRC) patients in relation to tumour advancement according to TNM classification, and tumour location. MATERIALS AND METHODS: The study group was composed of 53 CRC patients and 25 healthy subjects. Plasma levels of soluble P-, L- and E-selectins were measured using the immunoenzymatic method with Quantikine kits (R&D Systems, Minneapolis, MN). RESULTS: The mean levels of all selectins were significantly higher in CRC patients compared to healthy controls. The highest level of sP-selectin was observed in patients with metastases to the liver (stage IV), and was significantly higher than in patients without metastases (stage I/II) and with lymph node metastases (stage III), p = .02. The highest levels of sL- and sE-selectin were observed in patients with lymph node metastasis. We also found sP-selectin to be the best predictor of CRC. CONCLUSION: Our finding show possible involvement of tested selectins in CRC advancement and forming metastasis. Among sL- and E- selectins, P-selectin plays an important role in the progression of CRC and could be an attractive biomarker with clinical significance.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Biomarcadores Tumorais / Moléculas de Adesão Celular / Selectina-P Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Biomarcadores Tumorais / Moléculas de Adesão Celular / Selectina-P Idioma: En Ano de publicação: 2017 Tipo de documento: Article