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Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages.
Stucki, David; Brites, Daniela; Jeljeli, Leïla; Coscolla, Mireia; Liu, Qingyun; Trauner, Andrej; Fenner, Lukas; Rutaihwa, Liliana; Borrell, Sonia; Luo, Tao; Gao, Qian; Kato-Maeda, Midori; Ballif, Marie; Egger, Matthias; Macedo, Rita; Mardassi, Helmi; Moreno, Milagros; Tudo Vilanova, Griselda; Fyfe, Janet; Globan, Maria; Thomas, Jackson; Jamieson, Frances; Guthrie, Jennifer L; Asante-Poku, Adwoa; Yeboah-Manu, Dorothy; Wampande, Eddie; Ssengooba, Willy; Joloba, Moses; Henry Boom, W; Basu, Indira; Bower, James; Saraiva, Margarida; Vaconcellos, Sidra E G; Suffys, Philip; Koch, Anastasia; Wilkinson, Robert; Gail-Bekker, Linda; Malla, Bijaya; Ley, Serej D; Beck, Hans-Peter; de Jong, Bouke C; Toit, Kadri; Sanchez-Padilla, Elisabeth; Bonnet, Maryline; Gil-Brusola, Ana; Frank, Matthias; Penlap Beng, Veronique N; Eisenach, Kathleen; Alani, Issam; Wangui Ndung'u, Perpetual.
Afiliação
  • Stucki D; Swiss Tropical and Public Health Institute, Basel, Switzerland.
  • Brites D; University of Basel, Switzerland.
  • Jeljeli L; Swiss Tropical and Public Health Institute, Basel, Switzerland.
  • Coscolla M; University of Basel, Switzerland.
  • Liu Q; Forschungszentrum Borstel, Germany.
  • Trauner A; Institut Pasteur de Tunis, Université de Tunis El Manar, Tunis, Tunisia.
  • Fenner L; Swiss Tropical and Public Health Institute, Basel, Switzerland.
  • Rutaihwa L; University of Basel, Switzerland.
  • Borrell S; The Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Institutes of Biomedical Sciences and Institute of Medical Microbiology, School of Basic Medical Science of Fudan University, Shanghai, China.
  • Luo T; Swiss Tropical and Public Health Institute, Basel, Switzerland.
  • Gao Q; University of Basel, Switzerland.
  • Kato-Maeda M; Swiss Tropical and Public Health Institute, Basel, Switzerland.
  • Ballif M; University of Basel, Switzerland.
  • Egger M; Institute for Social and Preventive Medicine, University of Bern, Switzerland.
  • Macedo R; Swiss Tropical and Public Health Institute, Basel, Switzerland.
  • Mardassi H; University of Basel, Switzerland.
  • Moreno M; Swiss Tropical and Public Health Institute, Basel, Switzerland.
  • Tudo Vilanova G; University of Basel, Switzerland.
  • Fyfe J; Laboratory of Infection and Immunity, School of Basic Medical Science, West China Center of Medical Sciences, Sichuan University, Chengdu, Sichuan 610041, China.
  • Globan M; The Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Institutes of Biomedical Sciences and Institute of Medical Microbiology, School of Basic Medical Science of Fudan University, Shanghai, China.
  • Thomas J; School of Medicine, University of California, San Francisco, USA.
  • Jamieson F; Swiss Tropical and Public Health Institute, Basel, Switzerland.
  • Guthrie JL; University of Basel, Switzerland.
  • Asante-Poku A; Institute for Social and Preventive Medicine, University of Bern, Switzerland.
  • Yeboah-Manu D; Institute for Social and Preventive Medicine, University of Bern, Switzerland.
  • Wampande E; Laboratòrio de Saùde Publica, Lisbon, Portugal.
  • Ssengooba W; Institut Pasteur de Tunis, Université de Tunis El Manar, Tunis, Tunisia.
  • Joloba M; Hospital Nossa Senhora Da Paz, Cubal, Benguela, Angola.
  • Henry Boom W; Servei de Microbiologia, Hospital Clínic-ISGlobal, Barcelona, Spain.
  • Basu I; Victorian Infectious Diseases Reference Laboratory, Victoria, Australia.
  • Bower J; Victorian Infectious Diseases Reference Laboratory, Victoria, Australia.
  • Saraiva M; Ifakara Health Institute, Bagamoyo, Tanzania.
  • Vaconcellos SEG; Public Health Ontario, Toronto, Canada.
  • Suffys P; Public Health Ontario, Toronto, Canada.
  • Koch A; Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.
  • Wilkinson R; Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.
  • Gail-Bekker L; Department of Medical Microbiology, Makerere University, Kampala, Uganda.
  • Malla B; Department of Medical Microbiology, Makerere University, Kampala, Uganda.
  • Ley SD; Department of Global Health, University of Amsterdam, Amsterdam, the Netherlands.
  • Beck HP; Department of Medical Microbiology, Makerere University, Kampala, Uganda.
  • de Jong BC; Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, USA.
  • Toit K; LabPlus, Auckland City Hospital, Auckland, New Zealand.
  • Sanchez-Padilla E; LabPlus, Auckland City Hospital, Auckland, New Zealand.
  • Bonnet M; Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal.
  • Gil-Brusola A; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal.
  • Frank M; Oswaldo Cruz Institute, Brazil.
  • Penlap Beng VN; Oswaldo Cruz Institute, Brazil.
  • Eisenach K; Institute of Infectious Disease and Molecular Medicine and Department of Clinical Laboratory Sciences, University of Cape Town, South Africa.
  • Alani I; Institute of Infectious Disease and Molecular Medicine and Department of Clinical Laboratory Sciences, University of Cape Town, South Africa.
  • Wangui Ndung'u P; Department of Medicine, Imperial College London, UK.
Nat Genet ; 48(12): 1535-1543, 2016 12.
Article em En | MEDLINE | ID: mdl-27798628
ABSTRACT
Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Tuberculose / DNA Bacteriano / Genômica / Mycobacterium tuberculosis Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Tuberculose / DNA Bacteriano / Genômica / Mycobacterium tuberculosis Idioma: En Ano de publicação: 2016 Tipo de documento: Article