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Opposing Roles of Wnt Inhibitors IGFBP-4 and Dkk1 in Cardiac Ischemia by Differential Targeting of LRP5/6 and ß-catenin.
Wo, Da; Peng, Jinhui; Ren, Dan-Ni; Qiu, Liman; Chen, Jinxiao; Zhu, Ye; Yan, Yingjing; Yan, Hongwei; Wu, Jian; Ma, En; Zhong, Tao P; Chen, Yihan; Liu, Zhongmin; Liu, Shangfeng; Ao, Luoquan; Liu, Zhenping; Jiang, Cizhong; Peng, Jun; Zou, Yunzeng; Qian, Qirong; Zhu, Weidong.
Afiliação
  • Wo D; From Clinical and Translational Research Center Shanghai East Hospital, Key Laboratory of Arrhythmias, Ministry of Education, Tongji University School of Medicine, China (D.W., Jinhui Peng, D.-n.R., J.C., Y. Zhu, Y.Y., H.Y., E.M., Y.C., Zhongmin Liu, S.L., L.A., W.Z.); Department of Orthopedics, Cha
  • Peng J; From Clinical and Translational Research Center Shanghai East Hospital, Key Laboratory of Arrhythmias, Ministry of Education, Tongji University School of Medicine, China (D.W., Jinhui Peng, D.-n.R., J.C., Y. Zhu, Y.Y., H.Y., E.M., Y.C., Zhongmin Liu, S.L., L.A., W.Z.); Department of Orthopedics, Cha
  • Ren DN; From Clinical and Translational Research Center Shanghai East Hospital, Key Laboratory of Arrhythmias, Ministry of Education, Tongji University School of Medicine, China (D.W., Jinhui Peng, D.-n.R., J.C., Y. Zhu, Y.Y., H.Y., E.M., Y.C., Zhongmin Liu, S.L., L.A., W.Z.); Department of Orthopedics, Cha
  • Qiu L; From Clinical and Translational Research Center Shanghai East Hospital, Key Laboratory of Arrhythmias, Ministry of Education, Tongji University School of Medicine, China (D.W., Jinhui Peng, D.-n.R., J.C., Y. Zhu, Y.Y., H.Y., E.M., Y.C., Zhongmin Liu, S.L., L.A., W.Z.); Department of Orthopedics, Cha
  • Chen J; From Clinical and Translational Research Center Shanghai East Hospital, Key Laboratory of Arrhythmias, Ministry of Education, Tongji University School of Medicine, China (D.W., Jinhui Peng, D.-n.R., J.C., Y. Zhu, Y.Y., H.Y., E.M., Y.C., Zhongmin Liu, S.L., L.A., W.Z.); Department of Orthopedics, Cha
  • Zhu Y; From Clinical and Translational Research Center Shanghai East Hospital, Key Laboratory of Arrhythmias, Ministry of Education, Tongji University School of Medicine, China (D.W., Jinhui Peng, D.-n.R., J.C., Y. Zhu, Y.Y., H.Y., E.M., Y.C., Zhongmin Liu, S.L., L.A., W.Z.); Department of Orthopedics, Cha
  • Yan Y; From Clinical and Translational Research Center Shanghai East Hospital, Key Laboratory of Arrhythmias, Ministry of Education, Tongji University School of Medicine, China (D.W., Jinhui Peng, D.-n.R., J.C., Y. Zhu, Y.Y., H.Y., E.M., Y.C., Zhongmin Liu, S.L., L.A., W.Z.); Department of Orthopedics, Cha
  • Yan H; From Clinical and Translational Research Center Shanghai East Hospital, Key Laboratory of Arrhythmias, Ministry of Education, Tongji University School of Medicine, China (D.W., Jinhui Peng, D.-n.R., J.C., Y. Zhu, Y.Y., H.Y., E.M., Y.C., Zhongmin Liu, S.L., L.A., W.Z.); Department of Orthopedics, Cha
  • Wu J; From Clinical and Translational Research Center Shanghai East Hospital, Key Laboratory of Arrhythmias, Ministry of Education, Tongji University School of Medicine, China (D.W., Jinhui Peng, D.-n.R., J.C., Y. Zhu, Y.Y., H.Y., E.M., Y.C., Zhongmin Liu, S.L., L.A., W.Z.); Department of Orthopedics, Cha
  • Ma E; From Clinical and Translational Research Center Shanghai East Hospital, Key Laboratory of Arrhythmias, Ministry of Education, Tongji University School of Medicine, China (D.W., Jinhui Peng, D.-n.R., J.C., Y. Zhu, Y.Y., H.Y., E.M., Y.C., Zhongmin Liu, S.L., L.A., W.Z.); Department of Orthopedics, Cha
  • Zhong TP; From Clinical and Translational Research Center Shanghai East Hospital, Key Laboratory of Arrhythmias, Ministry of Education, Tongji University School of Medicine, China (D.W., Jinhui Peng, D.-n.R., J.C., Y. Zhu, Y.Y., H.Y., E.M., Y.C., Zhongmin Liu, S.L., L.A., W.Z.); Department of Orthopedics, Cha
  • Chen Y; From Clinical and Translational Research Center Shanghai East Hospital, Key Laboratory of Arrhythmias, Ministry of Education, Tongji University School of Medicine, China (D.W., Jinhui Peng, D.-n.R., J.C., Y. Zhu, Y.Y., H.Y., E.M., Y.C., Zhongmin Liu, S.L., L.A., W.Z.); Department of Orthopedics, Cha
  • Liu Z; From Clinical and Translational Research Center Shanghai East Hospital, Key Laboratory of Arrhythmias, Ministry of Education, Tongji University School of Medicine, China (D.W., Jinhui Peng, D.-n.R., J.C., Y. Zhu, Y.Y., H.Y., E.M., Y.C., Zhongmin Liu, S.L., L.A., W.Z.); Department of Orthopedics, Cha
  • Liu S; From Clinical and Translational Research Center Shanghai East Hospital, Key Laboratory of Arrhythmias, Ministry of Education, Tongji University School of Medicine, China (D.W., Jinhui Peng, D.-n.R., J.C., Y. Zhu, Y.Y., H.Y., E.M., Y.C., Zhongmin Liu, S.L., L.A., W.Z.); Department of Orthopedics, Cha
  • Ao L; From Clinical and Translational Research Center Shanghai East Hospital, Key Laboratory of Arrhythmias, Ministry of Education, Tongji University School of Medicine, China (D.W., Jinhui Peng, D.-n.R., J.C., Y. Zhu, Y.Y., H.Y., E.M., Y.C., Zhongmin Liu, S.L., L.A., W.Z.); Department of Orthopedics, Cha
  • Liu Z; From Clinical and Translational Research Center Shanghai East Hospital, Key Laboratory of Arrhythmias, Ministry of Education, Tongji University School of Medicine, China (D.W., Jinhui Peng, D.-n.R., J.C., Y. Zhu, Y.Y., H.Y., E.M., Y.C., Zhongmin Liu, S.L., L.A., W.Z.); Department of Orthopedics, Cha
  • Jiang C; From Clinical and Translational Research Center Shanghai East Hospital, Key Laboratory of Arrhythmias, Ministry of Education, Tongji University School of Medicine, China (D.W., Jinhui Peng, D.-n.R., J.C., Y. Zhu, Y.Y., H.Y., E.M., Y.C., Zhongmin Liu, S.L., L.A., W.Z.); Department of Orthopedics, Cha
  • Peng J; From Clinical and Translational Research Center Shanghai East Hospital, Key Laboratory of Arrhythmias, Ministry of Education, Tongji University School of Medicine, China (D.W., Jinhui Peng, D.-n.R., J.C., Y. Zhu, Y.Y., H.Y., E.M., Y.C., Zhongmin Liu, S.L., L.A., W.Z.); Department of Orthopedics, Cha
  • Zou Y; From Clinical and Translational Research Center Shanghai East Hospital, Key Laboratory of Arrhythmias, Ministry of Education, Tongji University School of Medicine, China (D.W., Jinhui Peng, D.-n.R., J.C., Y. Zhu, Y.Y., H.Y., E.M., Y.C., Zhongmin Liu, S.L., L.A., W.Z.); Department of Orthopedics, Cha
  • Qian Q; From Clinical and Translational Research Center Shanghai East Hospital, Key Laboratory of Arrhythmias, Ministry of Education, Tongji University School of Medicine, China (D.W., Jinhui Peng, D.-n.R., J.C., Y. Zhu, Y.Y., H.Y., E.M., Y.C., Zhongmin Liu, S.L., L.A., W.Z.); Department of Orthopedics, Cha
  • Zhu W; From Clinical and Translational Research Center Shanghai East Hospital, Key Laboratory of Arrhythmias, Ministry of Education, Tongji University School of Medicine, China (D.W., Jinhui Peng, D.-n.R., J.C., Y. Zhu, Y.Y., H.Y., E.M., Y.C., Zhongmin Liu, S.L., L.A., W.Z.); Department of Orthopedics, Cha
Circulation ; 134(24): 1991-2007, 2016 Dec 13.
Article em En | MEDLINE | ID: mdl-27803037
Assuntos
Proteína 4 de Ligação a Fator de Crescimento Semelhante à Insulina/farmacologia; Peptídeos e Proteínas de Sinalização Intercelular/farmacologia; Proteína-5 Relacionada a Receptor de Lipoproteína de Baixa Densidade/metabolismo; Proteína-6 Relacionada a Receptor de Lipoproteína de Baixa Densidade/metabolismo; Isquemia Miocárdica/patologia; Via de Sinalização Wnt/efeitos dos fármacos; beta Catenina/metabolismo; Animais; Dano ao DNA/efeitos dos fármacos; Modelos Animais de Doenças; Regulação para Baixo/efeitos dos fármacos; Histonas/metabolismo; Peróxido de Hidrogênio/toxicidade; Proteína 4 de Ligação a Fator de Crescimento Semelhante à Insulina/genética; Proteína 4 de Ligação a Fator de Crescimento Semelhante à Insulina/uso terapêutico; Peptídeos e Proteínas de Sinalização Intercelular/genética; Peptídeos e Proteínas de Sinalização Intercelular/uso terapêutico; Proteína-5 Relacionada a Receptor de Lipoproteína de Baixa Densidade/antagonistas & inibidores; Proteína-5 Relacionada a Receptor de Lipoproteína de Baixa Densidade/genética; Proteína-6 Relacionada a Receptor de Lipoproteína de Baixa Densidade/antagonistas & inibidores; Proteína-6 Relacionada a Receptor de Lipoproteína de Baixa Densidade/genética; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Isquemia Miocárdica/metabolismo; Isquemia Miocárdica/prevenção & controle; Miócitos Cardíacos/citologia; Miócitos Cardíacos/metabolismo; Interferência de RNA; RNA Interferente Pequeno/metabolismo; Proteínas Recombinantes/biossíntese; Proteínas Recombinantes/farmacologia; Proteínas Recombinantes/uso terapêutico; Proteínas Wnt/antagonistas & inibidores; Proteínas Wnt/metabolismo; beta Catenina/antagonistas & inibidores; beta Catenina/genética
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Base de dados: MEDLINE Assunto principal: Isquemia Miocárdica / Proteína 4 de Ligação a Fator de Crescimento Semelhante à Insulina / Peptídeos e Proteínas de Sinalização Intercelular / Beta Catenina / Proteína-5 Relacionada a Receptor de Lipoproteína de Baixa Densidade / Proteína-6 Relacionada a Receptor de Lipoproteína de Baixa Densidade / Via de Sinalização Wnt Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Buscar no Google
Imprimir
XML
PubMed Links

Base de dados: MEDLINE Assunto principal: Isquemia Miocárdica / Proteína 4 de Ligação a Fator de Crescimento Semelhante à Insulina / Peptídeos e Proteínas de Sinalização Intercelular / Beta Catenina / Proteína-5 Relacionada a Receptor de Lipoproteína de Baixa Densidade / Proteína-6 Relacionada a Receptor de Lipoproteína de Baixa Densidade / Via de Sinalização Wnt Idioma: En Ano de publicação: 2016 Tipo de documento: Article