The role of genetics in coronary artery bypass surgery patients under 30 years of age.
Cardiovasc J Afr
; 28(2): 77-80, 2017.
Article
em En
| MEDLINE
| ID: mdl-27805237
ABSTRACT
AIM:
We undertook genetic assessment of coronary artery disease (CAD) in 20 patients aged 30 years or less undergoing coronary artery bypass grafting (CABG) surgery, to investigate the prognostic value of pre-defined genes.METHODS:
Twenty patients, who underwent CABG surgery between December 2001 and May 2013, were retrospectively analysed to find out the role their genetic make-up played in their disease. We used three genetic diagnostic tests, the plasminogen activator inhibitor (PAI) -1 gene, the A1/A2 polymorphism of glycoprotein IIIa (GpIIIa) gene, and common polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene.RESULTS:
The mean age of patients was 26.35 ± 3.51 (19-30) years, and 90% were male (n = 18). One patient had diabetes, three had hypertension, 11 (55%) had dyslipidaemia and 16 (80%) were smokers. Eight of the patients (40%) had left ventricular ejection fraction (LVEF) < 50%, and functional capacity was poor in only two (10%) patients (NYHA III-IV). Follow up was completed in all patients (100%). We found five homozygous and 11 heterozygous mutations in the MTHFR gene, which predisposes individuals to coronary artery disease or deep-vein thrombosis. Eight patients were found to have a GpIIIa gene polymorphism, which is associated with increased risk of myocardial infarction (MI). Fifteen patients had a polymorphism in the promoter region of the PAI-1 gene, which is a major inhibitor of the fibrinolytic system.CONCLUSION:
MTHFR C677T polymorphism, and GpIIIa and PAI-1 genes are risk factors for CAD. In young patients, genetic studies promise to revolutionise early diagnosis, treatment and prevention of CAD and MI.
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Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
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Doença da Artéria Coronariana
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Ponte de Artéria Coronária
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Inibidor 1 de Ativador de Plasminogênio
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Integrina beta3
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Metilenotetra-Hidrofolato Redutase (NADPH2)
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Mutação
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article