Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation.

McDonnell, Eoin; Crown, Scott B; Fox, Douglas B; Kitir, Betül; Ilkayeva, Olga R; Olsen, Christian A; Grimsrud, Paul A; Hirschey, Matthew D

McDonnell, Eoin; Crown, Scott B; Fox, Douglas B; Kitir, Betül; Ilkayeva, Olga R; Olsen, Christian A; Grimsrud, Paul A; Hirschey, Matthew D.

Afiliação

McDonnell E; Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, 300 N Duke Street, Durham, NC 27701, USA; Department of Medicine, Duke University, Durham, NC 27710, USA.
Crown SB; Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, 300 N Duke Street, Durham, NC 27701, USA.
Fox DB; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.
Kitir B; Center for Biopharmaceuticals & Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
Ilkayeva OR; Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, 300 N Duke Street, Durham, NC 27701, USA.
Olsen CA; Center for Biopharmaceuticals & Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
Grimsrud PA; Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, 300 N Duke Street, Durham, NC 27701, USA.
Hirschey MD; Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, 300 N Duke Street, Durham, NC 27701, USA; Department of Medicine, Duke University, Durham, NC 27710, USA; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA. Electronic addres

Cell Rep ; 17(6): 1463-1472, 2016 11 01.

Article em En | MEDLINE | ID: mdl-27806287

Assuntos

Caprilatos/farmacologia; Carbono/farmacologia; Histonas/metabolismo; Metabolismo dos Lipídeos/efeitos dos fármacos; Acetilcoenzima A/metabolismo; Acetilação/efeitos dos fármacos; Sequência de Aminoácidos; Animais; Linhagem Celular Tumoral; Perfilação da Expressão Gênica; Regulação da Expressão Gênica/efeitos dos fármacos; Inibidores de Histona Desacetilases/farmacologia; Histonas/química; Humanos; Metabolismo dos Lipídeos/genética; Camundongos; Oxirredução

Palavras-chave

acetylation; epigenetics; fatty acid; gene expression; histone; lipids; metabolism; metabolomics; proteomics

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Caprilatos / Carbono / Histonas / Metabolismo dos Lipídeos Idioma: En Ano de publicação: 2016 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google