Two-layer sheet of gelatin: A new topical hemostatic agent.
Asian J Surg
; 41(2): 124-130, 2018 Mar.
Article
em En
| MEDLINE
| ID: mdl-27816406
ABSTRACT
BACKGROUND/OBJECTIVE:
Uncontrolled surgical bleeding is associated with increased morbidity, mortality, and hospital cost. Topical hemostatic agents available today have problems controlling hemostatic effects; furthermore, their handling is difficult and they are unsafe.METHODS:
We devised a new hemostatic agent comprising gelatin sponge and film designed to be applied to the bleeding site, thereby creating a topical hemostatic agent made of gelatin alone. The gelatin was prepared by alkali treatment to eliminate viral activity. Hemostatic effects, surgical handling, and tissue reactions of the materials, namely a two-layer sheet of gelatin, TachoSil, and gelatin sponge, were evaluated using 21 dogs' spleens.RESULTS:
The two-layer gelatin sheet and gelatin sponge exhibited superior hemostatic effects (100% hemostasis completed) compared with TachoSil (0-17% hemostasis). The gelatin matrix immediately absorbed blood flowing from wounds and activated the autologous components in the absorbed blood that promoted coagulation at the bleeding site. The two-layer gelatin sheet had the best surgical handling among the evaluated materials. Materials made of gelatin were associated with fewer inflammatory reactions compared with materials of TachoSil.CONCLUSION:
The two-layer sheet of gelatin is a useful topical agent because of its superior hemostatic effects and usability, and is associated with a lower risk of transmitting diseases and inflammatory reactions.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Esplenectomia
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Fibrinogênio
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Hemostáticos
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Trombina
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Hemorragia Pós-Operatória
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article