Tumor-induced Osteomalacia in a 3-Year-Old With Unresectable Central Giant Cell Lesions.
J Pediatr Hematol Oncol
; 39(1): e21-e24, 2017 01.
Article
em En
| MEDLINE
| ID: mdl-27820122
ABSTRACT
Tumor-induced osteomalacia (TIO) is a rare cause of hypophosphatemia involving overproduction of fibroblast growth factor 23. TIO has been described largely in adults with small mesenchymal tumors. We report a case of TIO in a child who presented with knee pain and radiographic findings concerning for rickets, and was found to have maxillomandibular giant cell lesions. The patient was treated with oral phosphorus and calcitriol, surgical debulking, and intralesional corticosteroids, which resulted in tumor regression and normalization of serum fibroblast growth factor 23 and phosphorus. This case illustrates the occurrence of this rare paraneoplastic syndrome in children and adds to our knowledge about clinical manifestations and pathologic findings associated with pediatric TIO.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Osteomalacia
/
Síndromes Paraneoplásicas
/
Neoplasias Mandibulares
/
Neoplasias Maxilares
/
Tumores de Células Gigantes
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article