Novel 5-nitropyrimidine derivatives bearing endo-azabicyclic alcohols/amines as potent GPR119 agonists.

Fang, Yuanying; Yang, Zunhua; Gundeti, Shankariah; Lee, Jongkook; Park, Haeil

Fang, Yuanying; Yang, Zunhua; Gundeti, Shankariah; Lee, Jongkook; Park, Haeil.

Afiliação

Fang Y; College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
Yang Z; College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
Gundeti S; College of Pharmacy of Kangwon National University, Chuncheon 200-701, Republic of Korea.
Lee J; College of Pharmacy of Kangwon National University, Chuncheon 200-701, Republic of Korea.
Park H; College of Pharmacy of Kangwon National University, Chuncheon 200-701, Republic of Korea. Electronic address: haeilp@kangwon.ac.kr.

Bioorg Med Chem ; 25(1): 254-260, 2017 01 01.

Article em En | MEDLINE | ID: mdl-27825553

Assuntos

Pirimidinas/farmacologia; Receptores Acoplados a Proteínas G/agonistas; Sulfonas/farmacologia; Tropanos/farmacologia; Células HEK293; Humanos; Pirimidinas/síntese química; Sulfonas/síntese química; Tropanos/síntese química

Palavras-chave

5-Nitropyrimidine; Full agonists; GPR119 agonists; endo-Azabicyclic alcohol

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Sulfonas / Tropanos / Receptores Acoplados a Proteínas G Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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