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Potent Inducers of Endogenous Antimicrobial Peptides for Host Directed Therapy of Infections.
Ottosson, H; Nylén, F; Sarker, P; Miraglia, E; Bergman, P; Gudmundsson, G H; Raqib, R; Agerberth, B; Strömberg, R.
Afiliação
  • Ottosson H; Department of Biosciences and Nutrition, Karolinska Institutet, S-14183, Huddinge, Sweden.
  • Nylén F; Department of Laboratory Medicine, Karolinska Institutet, S-14186, Huddinge, Sweden.
  • Sarker P; International Center for Diarrheal Disease Research, Bangladesh (icddr, b) Dhaka, Bangladesh.
  • Miraglia E; Department of Laboratory Medicine, Karolinska Institutet, S-14186, Huddinge, Sweden.
  • Bergman P; Department of Laboratory Medicine, Karolinska Institutet, S-14186, Huddinge, Sweden.
  • Gudmundsson GH; Biomedical Center, University of Iceland, Reykjavik, Iceland.
  • Raqib R; International Center for Diarrheal Disease Research, Bangladesh (icddr, b) Dhaka, Bangladesh.
  • Agerberth B; Department of Laboratory Medicine, Karolinska Institutet, S-14186, Huddinge, Sweden.
  • Strömberg R; Department of Biosciences and Nutrition, Karolinska Institutet, S-14183, Huddinge, Sweden.
Sci Rep ; 6: 36692, 2016 11 09.
Article em En | MEDLINE | ID: mdl-27827460
ABSTRACT
A new concept for treatment of infections is induction of our own antimicrobial peptides and the presented novel class of inducer, aroylated phenylenediamines (APDs), gives up to 20 to 30-fold induction of the human antimicrobial peptide LL-37, in vitro. In addition, oral administration of an APD in a rabbit model of Shigellosis resulted in recovery from the infection in a few days implying that APD's are promising candidates for treatment of infections.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fenilenodiaminas / Peptídeos Catiônicos Antimicrobianos / Disenteria Bacilar Idioma: En Ano de publicação: 2016 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fenilenodiaminas / Peptídeos Catiônicos Antimicrobianos / Disenteria Bacilar Idioma: En Ano de publicação: 2016 Tipo de documento: Article