Cyclic-di-GMP binding induces structural rearrangements in the PlzA and PlzC proteins of the Lyme disease and relapsing fever spirochetes: a possible switch mechanism for c-di-GMP-mediated effector functions.

Mallory, Katherine L; Miller, Daniel P; Oliver, Lee D; Freedman, John C; Kostick-Dunn, Jessica L; Carlyon, Jason A; Marion, James D; Bell, Jessica K; Marconi, Richard T

Mallory, Katherine L; Miller, Daniel P; Oliver, Lee D; Freedman, John C; Kostick-Dunn, Jessica L; Carlyon, Jason A; Marion, James D; Bell, Jessica K; Marconi, Richard T.

Afiliação

Mallory KL; Department of Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, VA 23298-0678, USA.
Miller DP; Department of Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, VA 23298-0678, USA.
Oliver LD; Department of Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, VA 23298-0678, USA.
Freedman JC; Department of Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, VA 23298-0678, USA.
Kostick-Dunn JL; Department of Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, VA 23298-0678, USA.
Carlyon JA; Department of Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, VA 23298-0678, USA.
Marion JD; Department of Chemistry and Biochemistry, University of California-San Diego, San Diego, CA 92110-8001, USA.
Bell JK; University of California-San Diego, San Diego, CA 92110-8001, USA.
Marconi RT; Department of Microbiology and Immunology, Virginia Commonwealth University Medical Center, Richmond, VA 23298-0678, USA richard.marconi@vcuhealth.org.

Pathog Dis ; 74(8)2016 11.

Article em En | MEDLINE | ID: mdl-27852620

Assuntos

Proteínas de Bactérias/metabolismo; GMP Cíclico/análogos & derivados; Doença de Lyme/microbiologia; Febre Recorrente/microbiologia; Spirochaetaceae/metabolismo; Substituição de Aminoácidos; Proteínas de Bactérias/química; Proteínas de Bactérias/genética; Borrelia burgdorferi/genética; Borrelia burgdorferi/metabolismo; GMP Cíclico/metabolismo; Humanos; Mutação; Ligação Proteica; Conformação Proteica; Multimerização Proteica; Spirochaetaceae/genética

Palavras-chave

Lyme disease; PlzA, Borrelia; Rrp1; c-di-GMP; relapsing fever

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Base de dados: MEDLINE Assunto principal: Febre Recorrente / Spirochaetaceae / Proteínas de Bactérias / Doença de Lyme / GMP Cíclico Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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