An Ex Vivo Tissue Culture Model for Anti-angiogenic Drug Testing.
Methods Mol Biol
; 1464: 85-95, 2016.
Article
em En
| MEDLINE
| ID: mdl-27858358
ABSTRACT
Angiogenesis, defined as the growth of new blood vessels from existing ones, plays a key role in development, growth, and tissue repair. Its necessary role in tumor growth and metastasis has led to the creation of a new category of anti-angiogenic cancer therapies. Preclinical development and evaluation of potential drug candidates require models that mimic real microvascular networks. Here, we describe the rat mesentery culture model as a simple ex vivo assay that offers time-lapse imaging of intact microvascular network remodeling and demonstrate its application for anti-angiogenic drug testing.
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Base de dados:
MEDLINE
Assunto principal:
Inibidores da Angiogênese
/
Técnicas de Cultura de Tecidos
/
Microvasos
/
Mesentério
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article