Intelligent Approach to Solvent Substitution: The Identification of a New Class of Levoglucosenone Derivatives.
ChemSusChem
; 9(24): 3503-3512, 2016 Dec 20.
Article
em En
| MEDLINE
| ID: mdl-27860452
ABSTRACT
With the increasing restriction and control of hazardous solvents, safer alternatives need to be identified. Here a contemporary approach to solvent selection and substitution is presented that offers a more scientific alternative to the simple "like-for-like" exchange. A new family of levoglucosenonederived compounds is proposed, modeled to determine their solvent properties, synthesized, and tested. These new molecules show promise as replacements for polar aprotic solvents that have chronic toxicity issues, such as dichloromethane, nitrobenzene, and N-methylpyrrolidinone. The success of this approach makes it possible for academia and industry to make calculated, intelligent choices for solvent substitution in the future.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Solventes
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Compostos Bicíclicos Heterocíclicos com Pontes
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Glucose
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article