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A Generic Multi-Compartmental CNS Distribution Model Structure for 9 Drugs Allows Prediction of Human Brain Target Site Concentrations.
Yamamoto, Yumi; Välitalo, Pyry A; van den Berg, Dirk-Jan; Hartman, Robin; van den Brink, Willem; Wong, Yin Cheong; Huntjens, Dymphy R; Proost, Johannes H; Vermeulen, An; Krauwinkel, Walter; Bakshi, Suruchi; Aranzana-Climent, Vincent; Marchand, Sandrine; Dahyot-Fizelier, Claire; Couet, William; Danhof, Meindert; van Hasselt, Johan G C; de Lange, Elizabeth C M.
Afiliação
  • Yamamoto Y; Division of Pharmacology, Cluster Systems Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
  • Välitalo PA; Division of Pharmacology, Cluster Systems Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
  • van den Berg DJ; Division of Pharmacology, Cluster Systems Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
  • Hartman R; Division of Pharmacology, Cluster Systems Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
  • van den Brink W; Division of Pharmacology, Cluster Systems Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
  • Wong YC; Division of Pharmacology, Cluster Systems Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
  • Huntjens DR; Quantitative Sciences, Janssen Research & Development, a Division of Janssen Pharmaceutica NV, Beerse, Belgium.
  • Proost JH; Division of Pharmacokinetics, Toxicology and Targeting, University of Groningen, Groningen, The Netherlands.
  • Vermeulen A; Quantitative Sciences, Janssen Research & Development, a Division of Janssen Pharmaceutica NV, Beerse, Belgium.
  • Krauwinkel W; Department of Clinical Pharmacology & Exploratory Development, Astellas Pharma BV, Leiden, The Netherlands.
  • Bakshi S; Division of Pharmacology, Cluster Systems Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
  • Aranzana-Climent V; Department of Medicine and Pharmacy, University of Poitiers, Poitiers, France.
  • Marchand S; Department of Medicine and Pharmacy, University of Poitiers, Poitiers, France.
  • Dahyot-Fizelier C; Department of Anaesthesiology and Intensive Care Medicine, University Hospital Center of Poitiers, Poitiers, France.
  • Couet W; Department of Medicine and Pharmacy, University of Poitiers, Poitiers, France.
  • Danhof M; Division of Pharmacology, Cluster Systems Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
  • van Hasselt JG; Division of Pharmacology, Cluster Systems Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
  • de Lange EC; Division of Pharmacology, Cluster Systems Pharmacology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands. ecmdelange@lacdr.leidenuniv.nl.
Pharm Res ; 34(2): 333-351, 2017 02.
Article em En | MEDLINE | ID: mdl-27864744
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Acetaminofen / Morfina Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Acetaminofen / Morfina Idioma: En Ano de publicação: 2017 Tipo de documento: Article