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Retinol dehydrogenase 13 deficiency diminishes carbon tetrachloride-induced liver fibrosis in mice.
Cui, Xiaofang; Dang, Suying; Wang, Yan; Chen, Yan; Zhou, Jia; Shen, Chunling; Kuang, Ying; Fei, Jian; Lu, Lungen; Wang, Zhugang.
Afiliação
  • Cui X; State Key Laboratory of Medical Genomics, Research Center for Experimental Medicine, Shanghai Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200025, China; Model Organism Division, E-Institutes of Shanghai Jiao Tong Universities School of Medicine
  • Dang S; State Key Laboratory of Medical Genomics, Research Center for Experimental Medicine, Shanghai Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200025, China; Shanghai Research Center for Model Organisms, Shanghai, 201203, China.
  • Wang Y; Department of Gastroenterology, Shanghai First People's Hospital Affiliated to SJTUSM, Shanghai, 200080, China.
  • Chen Y; State Key Laboratory of Medical Genomics, Research Center for Experimental Medicine, Shanghai Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200025, China.
  • Zhou J; State Key Laboratory of Medical Genomics, Research Center for Experimental Medicine, Shanghai Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200025, China.
  • Shen C; State Key Laboratory of Medical Genomics, Research Center for Experimental Medicine, Shanghai Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200025, China; Shanghai Research Center for Model Organisms, Shanghai, 201203, China.
  • Kuang Y; Shanghai Research Center for Model Organisms, Shanghai, 201203, China.
  • Fei J; Shanghai Research Center for Model Organisms, Shanghai, 201203, China.
  • Lu L; Department of Gastroenterology, Shanghai First People's Hospital Affiliated to SJTUSM, Shanghai, 200080, China.
  • Wang Z; State Key Laboratory of Medical Genomics, Research Center for Experimental Medicine, Shanghai Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, 200025, China; Model Organism Division, E-Institutes of Shanghai Jiao Tong Universities School of Medicine
Toxicol Lett ; 265: 17-22, 2017 Jan 04.
Article em En | MEDLINE | ID: mdl-27865848
ABSTRACT
Retinol dehydrogenase 13 (RDH13) is a mitochondrion-localized member of the short-chain dehydrogenases/reductases (SDRs) superfamily that participates in metabolism of some compounds. Rdh13 mRNA is most highly expressed in mouse liver. Rdh13 deficiency reduces the extent of liver injury and fibrosis, reduces hepatic stellate cell (HSC) activation, attenuates collagen I (II), tissue inhibitor of metalloproteinase 1 (TIMP-1) and transforming growth factor beta 1 (Tgf-ß1) expression. The results indicate an important role of Rdh13 and suggest RDH13 as a possible new therapeutic target for CCl4-induced fibrosis.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tetracloreto de Carbono / Oxirredutases do Álcool / Doença Hepática Induzida por Substâncias e Drogas / Cirrose Hepática Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tetracloreto de Carbono / Oxirredutases do Álcool / Doença Hepática Induzida por Substâncias e Drogas / Cirrose Hepática Idioma: En Ano de publicação: 2017 Tipo de documento: Article