Optically active stereoisomers of 5-(1-iodoethyl)-4-(4'-isopropylphenyl)dihydrofuran-2-one: The effect of the configuration of stereocenters on apoptosis induction in canine cancer cell lines.

Pawlak, Aleksandra; Gladkowski, Witold; Mazur, Marcelina; Henklewska, Marta; Obminska-Mrukowicz, Bozena; Rapak, Andrzej

Pawlak, Aleksandra; Gladkowski, Witold; Mazur, Marcelina; Henklewska, Marta; Obminska-Mrukowicz, Bozena; Rapak, Andrzej.

Afiliação

Pawlak A; Department of Biochemistry, Pharmacology and Toxicology, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Norwida 31, 50-375 Wroclaw, Poland. Electronic address: aleksandra.pawlak@up.wroc.pl.
Gladkowski W; Department of Chemistry, Faculty of Food Science, Wroclaw University of Environmental and Life Sciences, Norwida 25, 50-375 Wroclaw, Poland. Electronic address: glado@poczta.fm.
Mazur M; Department of Chemistry, Faculty of Food Science, Wroclaw University of Environmental and Life Sciences, Norwida 25, 50-375 Wroclaw, Poland. Electronic address: marcelina.mazur@up.wroc.pl.
Henklewska M; Department of Biochemistry, Pharmacology and Toxicology, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Norwida 31, 50-375 Wroclaw, Poland. Electronic address: marta.henklewska@up.wroc.pl.
Obminska-Mrukowicz B; Department of Biochemistry, Pharmacology and Toxicology, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Norwida 31, 50-375 Wroclaw, Poland. Electronic address: b.mrukowicz@gmail.com.
Rapak A; Laboratory of Tumor Molecular Immunobiology, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Wroclaw, Weigla 12, 53-114 Wroclaw, Poland. Electronic address: rapak@iitd.pan.wroc.pl.

Chem Biol Interact ; 261: 18-26, 2017 Jan 05.

Article em En | MEDLINE | ID: mdl-27867085

Assuntos

4-Butirolactona/análogos & derivados; Apoptose/efeitos dos fármacos; Furanos/farmacologia; Fenômenos Ópticos; 4-Butirolactona/química; 4-Butirolactona/farmacologia; Animais; Caspase 3/metabolismo; Caspase 7/metabolismo; Ciclo Celular/efeitos dos fármacos; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Cães; Ativação Enzimática/efeitos dos fármacos; Furanos/química; Lactonas/farmacologia; Estereoisomerismo

Palavras-chave

Apoptosis; Canine cancer cell lines; Canine cancers; Structureactivity relationship; ß-Aryl-Î´-iodo-Î³-lactones

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: 4-Butirolactona / Apoptose / Fenômenos Ópticos / Furanos Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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