Aminoalkyl Derivatives of 8-Alkoxypurine-2,6-diones: Multifunctional 5-HT<sub>1A</sub> /5-HT<sub>7</sub> Receptor Ligands and PDE Inhibitors with Antidepressant Activity.

Chlon-Rzepa, Grazyna; Zagórska, Agnieszka; Zmudzki, Pawel; Bucki, Adam; Kolaczkowski, Marcin; Partyka, Anna; Wesolowska, Anna; Kazek, Grzegorz; Gluch-Lutwin, Monika; Siwek, Agata; Starowicz, Gabriela; Pawlowski, Maciej

Aminoalkyl Derivatives of 8-Alkoxypurine-2,6-diones: Multifunctional 5-HT_1A /5-HT₇ Receptor Ligands and PDE Inhibitors with Antidepressant Activity.

Chlon-Rzepa, Grazyna; Zagórska, Agnieszka; Zmudzki, Pawel; Bucki, Adam; Kolaczkowski, Marcin; Partyka, Anna; Wesolowska, Anna; Kazek, Grzegorz; Gluch-Lutwin, Monika; Siwek, Agata; Starowicz, Gabriela; Pawlowski, Maciej.

Afiliação

Chlon-Rzepa G; Department of Medicinal Chemistry, Jagiellonian University Medical College, Kraków, Poland.
Zagórska A; Department of Medicinal Chemistry, Jagiellonian University Medical College, Kraków, Poland.
Zmudzki P; Department of Medicinal Chemistry, Jagiellonian University Medical College, Kraków, Poland.
Bucki A; Department of Medicinal Chemistry, Jagiellonian University Medical College, Kraków, Poland.
Kolaczkowski M; Department of Medicinal Chemistry, Jagiellonian University Medical College, Kraków, Poland.
Partyka A; Department of Clinical Pharmacy, Jagiellonian University Medical College, Kraków, Poland.
Wesolowska A; Department of Clinical Pharmacy, Jagiellonian University Medical College, Kraków, Poland.
Kazek G; Department of Pharmacological Screening, Jagiellonian University Medical College, Kraków, Poland.
Gluch-Lutwin M; Department of Pharmacological Screening, Jagiellonian University Medical College, Kraków, Poland.
Siwek A; Department of Pharmacobiology, Jagiellonian University Medical College, Kraków, Poland.
Starowicz G; Department of Pharmacobiology, Jagiellonian University Medical College, Kraków, Poland.
Pawlowski M; Department of Medicinal Chemistry, Jagiellonian University Medical College, Kraków, Poland.

Arch Pharm (Weinheim) ; 349(12): 889-903, 2016 Dec.

Article em En | MEDLINE | ID: mdl-27869315

Assuntos

Antidepressivos/farmacologia; Inibidores de Fosfodiesterase/farmacologia; Piperazinas/síntese química; Piperazinas/farmacologia; Antagonistas da Serotonina/farmacologia; Agonistas do Receptor de Serotonina/farmacologia; Animais; Antidepressivos/síntese química; Nucleotídeo Cíclico Fosfodiesterase do Tipo 4/efeitos dos fármacos; Resposta de Imobilidade Tônica/efeitos dos fármacos; Isoenzimas/antagonistas & inibidores; Isoquinolinas/síntese química; Isoquinolinas/farmacologia; Masculino; Camundongos; Modelos Moleculares; Inibidores de Fosfodiesterase/síntese química; Diester Fosfórico Hidrolases/efeitos dos fármacos; Receptores de Serotonina/efeitos dos fármacos; Antagonistas da Serotonina/síntese química; Agonistas do Receptor de Serotonina/síntese química; Relação Estrutura-Atividade; Teobromina/farmacologia; Teofilina/farmacologia

Palavras-chave

Depression; PDE inhibitors; Serotonin receptor ligands

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores de Fosfodiesterase / Piperazinas / Antagonistas da Serotonina / Agonistas do Receptor de Serotonina / Antidepressivos Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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