Synthesis and biological evaluation against Mycobacterium tuberculosis and Leishmania amazonensis of a series of diaminated terpenoids.
Biomed Pharmacother
; 84: 1739-1747, 2016 Dec.
Article
em En
| MEDLINE
| ID: mdl-27876209
ABSTRACT
We report the synthesis of a series of diaminated terpenoids containing, as side-chain of the diamine core, the "head-to-tail" prenyl derivatives, with amino amino spacers of variable length. In vitro biological activity of these compounds was evaluated against Mycobacterium tuberculosis and Leishmania amazonensis, and the structure-activity relationships are discussed. Different biological results were observed depending on the terpenic side-chain length. The best results were obtained for trans,trans-farnesol derivatives. Moreover, these results demonstrated that the stereochemistry of the double bond could play an important role in determining antitubercular and antileishmanial activities of these compounds.
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Base de dados:
MEDLINE
Assunto principal:
Terpenos
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Leishmania mexicana
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Diaminas
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Mycobacterium tuberculosis
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Antiprotozoários
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Antituberculosos
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article