Effect of Cardiac Myosin-Binding Protein C on Tropomyosin Regulation of Actin-Myosin Interaction Using In Vitro Motility Assay.
Bull Exp Biol Med
; 162(1): 45-47, 2016 Nov.
Article
em En
| MEDLINE
| ID: mdl-27878725
ABSTRACT
We studied the modulating role of cardiac myosin-binding protein C (cMyBP-C) in tropomyosin regulation of the actin-myosin interaction. The effect of cMyBP-C on the velocity of actin-tropomyosin filament sliding over cardiac and slow skeletal myosins was evaluated using in vitro motility assay. The effect of cMyBP-C on the actin-tropomyosin filaments sliding depended on the type of myosin. The regulatory effect of cMyBP-C differs for cardiac and slow skeletal myosin because of the presence of specific essential light chain (LC1sa) in slow skeletal myosin isoform.
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Base de dados:
MEDLINE
Assunto principal:
Tropomiosina
/
Proteínas de Transporte
/
Actinas
/
Miosinas
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article