Essential Role of mTORC1 in Self-Renewal of Murine Alveolar Macrophages.
J Immunol
; 198(1): 492-504, 2017 01 01.
Article
em En
| MEDLINE
| ID: mdl-27881705
ABSTRACT
Alveolar macrophages (AMÏ) have the capacity of local self-renewal through adult life; however, mechanisms that regulate AMÏ self-renewal remain poorly understood. We found that myeloid-specific deletion of Raptor, an essential component of the mammalian/mechanistic target of rapamycin complex (mTORC)1, resulted in a marked decrease of this population of cells accompanying altered phenotypic features and impaired phagocytosis activity. We demonstrated further that Raptor/mTORC1 deficiency did not affect AMÏ development, but compromised its proliferative activity at cell cycle entry in the steady-state as well as in the context of repopulation in irradiation chimeras. Mechanically, mTORC1 confers AMÏ optimal responsiveness to GM-CSF-induced proliferation. Thus, our results demonstrate an essential role of mTORC1 for AMÏ homeostasis by regulating proliferative renewal.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Macrófagos Alveolares
/
Complexos Multiproteicos
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Serina-Treonina Quinases TOR
/
Homeostase
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article