Tailoring Renal Clearance and Tumor Targeting of Ultrasmall Metal Nanoparticles with Particle Density.
Angew Chem Int Ed Engl
; 55(52): 16039-16043, 2016 12 23.
Article
em En
| MEDLINE
| ID: mdl-27882633
ABSTRACT
Identifying key factors that govern the inâ
vivo behavior of nanomaterials is critical to the clinical translation of nanomedicines. Overshadowed by size-, shape-, and surface-chemistry effects, the impact of the particle core density on clearance and tumor targeting of inorganic nanoparticles (NPs) remains largely unknown. By utilizing a class of ultrasmall metal NPs with the same size and surface chemistry but different densities, we found that the renal-clearance efficiency exponentially increased in the early elimination phase while passive tumor targeting linearly decreased with a decrease in particle density. Moreover, lower-density NPs are more easily distributed in the body and have shorter retention times in highly permeable organs than higher-density NPs. The density-dependent inâ
vivo behavior of metal NPs likely results from their distinct margination in laminar blood flow, which opens up a new path for precise control of nanomedicines in vivo.
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MEDLINE
Assunto principal:
Nanopartículas Metálicas
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Neoplasias
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article