Roux-en-Y gastric bypass augments the feeding responses evoked by gastrin-releasing peptides.
J Surg Res
; 206(2): 517-524, 2016 12.
Article
em En
| MEDLINE
| ID: mdl-27884350
ABSTRACT
BACKGROUND:
Roux-en-Y gastric bypass (RYGB) is the most effective method for the treatment of obesity, and metabolic disease RYGB may reduce body weight by altering the feeding responses evoked by the short-term satiety peptides. MATERIALS ANDMETHODS:
Here, we measured meal size (MS, chow), intermeal interval (IMI) length, and satiety ratio (SR, IMI/MS; food consumed per a unit of time) by the small and the large forms of gastrin-releasing peptide (GRP) in rats, GRP-10 and GRP-29 (0, 0.1, 0.5 nmol/kg) infused in the celiac artery (CA, supplies stomach and upper duodenum) and the cranial mesenteric artery (CMA, supplies small and large intestine) in an RYGB rat model.RESULTS:
GRP-10 reduced MS, prolonged the IMI, and increased the SR only in the RYGB group, whereas GRP-29 evoked these responses by both routes and in both groups.CONCLUSIONS:
The RYGB procedure augments the feeding responses evoked by exogenous GRP, possibly by decreasing total food intake, increasing latency to the first meal, decreasing number of meals or altering the sites of action regulating MS and IMI length by the two peptides.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Derivação Gástrica
/
Peptídeo Liberador de Gastrina
/
Comportamento Alimentar
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article