miR-146a rs2910164 and hepatocellular carcinoma: a meta-analysis.
Minerva Med
; 108(3): 287-292, 2017 Jun.
Article
em En
| MEDLINE
| ID: mdl-27886162
ABSTRACT
INTRODUCTION:
Single nucleotide polymorphism in miRNAs can alter its expression, thus can lead to the development of cancers. Many studies have explored the association between miR-146a rs2910164 (G>C) polymorphism and hepatocellular carcinoma (HCC) risk, but the results remains inconsistent. So, we performed this pooled analyses in order to get a precise result. EVIDENCE ACQUISITION Odds ratios (OR) with 95% conï¬dence intervals (CI), calculated by STATA software, was used to determine whether miR-146a rs2910164 polymorphism contributes to the risk of HCC. A comprehensive literature search was conducted on PubMed, Embase, Web of Science, and China National Knowledge Infrastructure up to May 30, 2016. EVIDENCESYNTHESIS:
A total of 14 studies including 5921 cases and 7005 controls were included in this meta-analysis. When all the eligible studies were pooled into this meta-analysis, the miR-146a rs2910164 was associated with a decreased risk of hepatocellular carcinoma (OR=0.90; 95% CI=0.82-0.98, P=0.01, allele model).CONCLUSIONS:
Our meta-analysis supports that the miR-146a rs2910164 polymorphism contributes to the risk of HCC from currently available evidence.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Carcinoma Hepatocelular
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Polimorfismo de Nucleotídeo Único
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MicroRNAs
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Neoplasias Hepáticas
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article