Identification of different ALK mutations in a pair of neuroblastoma cell lines established at diagnosis and relapse.

Chen, Lindi; Humphreys, Angharad; Turnbull, Lisa; Bellini, Angela; Schleiermacher, Gudrun; Salwen, Helen; Cohn, Susan L; Bown, Nick; Tweddle, Deborah A

Chen, Lindi; Humphreys, Angharad; Turnbull, Lisa; Bellini, Angela; Schleiermacher, Gudrun; Salwen, Helen; Cohn, Susan L; Bown, Nick; Tweddle, Deborah A.

Afiliação

Chen L; Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, NE1 7RU, United Kingdom.
Humphreys A; Northern Genetics Service, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Institute of Genetic Medicine, Central Parkway, Newcastle upon Tyne, NE1 3BZ, United Kingdom.
Turnbull L; Northern Genetics Service, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Institute of Genetic Medicine, Central Parkway, Newcastle upon Tyne, NE1 3BZ, United Kingdom.
Bellini A; Institut Curie, 75248 Paris cedex 05, France.
Schleiermacher G; Institut Curie, 75248 Paris cedex 05, France.
Salwen H; Department of Pediatrics, University of Chicago, Chicago, Illinois 60637, USA.
Cohn SL; Department of Pediatrics, University of Chicago, Chicago, Illinois 60637, USA.
Bown N; Northern Genetics Service, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Institute of Genetic Medicine, Central Parkway, Newcastle upon Tyne, NE1 3BZ, United Kingdom.
Tweddle DA; Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, NE1 7RU, United Kingdom.

Oncotarget ; 7(52): 87301-87311, 2016 Dec 27.

Article em En | MEDLINE | ID: mdl-27888620

Assuntos

Mutação; Neuroblastoma/genética; Receptores Proteína Tirosina Quinases/genética; Quinase do Linfoma Anaplásico; Apoptose/efeitos dos fármacos; Linhagem Celular Tumoral; Hibridização Genômica Comparativa; Humanos; Repetições de Microssatélites; Neuroblastoma/tratamento farmacológico; Neuroblastoma/patologia; Inibidores de Proteínas Quinases/uso terapêutico; RNA Mensageiro/análise; Receptores Proteína Tirosina Quinases/antagonistas & inibidores

Palavras-chave

ALK; F1174L; R1275L; neuroblastoma; paired cell lines

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores Proteína Tirosina Quinases / Mutação / Neuroblastoma Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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