Head-and-neck squamous cell carcinoma risk in smokers: no association detected between phenotype and AHR, CYP1A1, CYP1A2, or CYP1B1 genotype.

Jorge-Nebert, Lucia F; Zhang, Ge; Wilson, Keith M; Jiang, Zhengwen; Butler, Randall; Gluckman, Jack L; Pinney, Susan M; Nebert, Daniel W

Jorge-Nebert, Lucia F; Zhang, Ge; Wilson, Keith M; Jiang, Zhengwen; Butler, Randall; Gluckman, Jack L; Pinney, Susan M; Nebert, Daniel W.

Afiliação

Jorge-Nebert LF; Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH, 45267-0056, USA.
Zhang G; Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH, 45267-0056, USA.
Wilson KM; Division of Human Genetics, Department of Pediatrics & Molecular Developmental Biology, Cincinnati Children's Hospital, Cincinnati, Ohio, 45229-2899, USA.
Jiang Z; Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, 45267-0528, USA.
Butler R; Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH, 45267-0056, USA.
Gluckman JL; Present address: Genesky Diagnostics, Suzhou, China.
Pinney SM; Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, 45267-0533, USA.
Nebert DW; Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, 45267-0528, USA.

Hum Genomics ; 10(1): 39, 2016 11 28.

Article em En | MEDLINE | ID: mdl-27894333

Assuntos

Fatores de Transcrição Hélice-Alça-Hélice Básicos/genética; Carcinoma de Células Escamosas/genética; Citocromo P-450 CYP1A1/genética; Citocromo P-450 CYP1A2/genética; Citocromo P-450 CYP1B1/genética; Neoplasias de Cabeça e Pescoço/genética; Receptores de Hidrocarboneto Arílico/genética; Estudos de Casos e Controles; Frequência do Gene; Estudos de Associação Genética; Predisposição Genética para Doença; Haplótipos; Humanos; Desequilíbrio de Ligação; Polimorfismo de Nucleotídeo Único; Fumar/efeitos adversos

Palavras-chave

AHR gene; CYP1A1; CYP1A2; CYP1B1 genes; Candidate-gene approach to genotype-phenotype association; Cigarette smoking; Extreme discordant phenotype method; Head-and-neck squamous cell carcinoma (HNSCC); Population stratification; Tag-SNPs (single nucleotide polymorphisms)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma de Células Escamosas / Receptores de Hidrocarboneto Arílico / Citocromo P-450 CYP1A1 / Citocromo P-450 CYP1A2 / Fatores de Transcrição Hélice-Alça-Hélice Básicos / Citocromo P-450 CYP1B1 / Neoplasias de Cabeça e Pescoço Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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