Significant Role of Segmental Duplications and SIDD Sites in Chromosomal Translocations of Hematological Malignancies: A Multi-parametric Bioinformatic Analysis.

Daga, Aditi; Ansari, Afzal; Pandya, Medha; Shah, Krupa; Patel, Shanaya; Rawal, Rakesh; Umrania, Valentina

Daga, Aditi; Ansari, Afzal; Pandya, Medha; Shah, Krupa; Patel, Shanaya; Rawal, Rakesh; Umrania, Valentina.

Afiliação

Daga A; Department of Microbiology, MVM Science College, Saurashtra University, Near Under Bridge, Kalawad Road, Rajkot, Gujarat, 360007, India.
Ansari A; BIT Virtual Institute of Bioinformatics (GCRI Node), GSBTM, Gandhinagar, Gujarat, India.
Pandya M; BIT Virtual Institute of Bioinformatics (GCRI Node), Division of Medicinal Chemistry and Pharmacogenomics, The Gujarat Cancer and Research Institute, NCH Campus, Asarwa, Ahmedabad, Gujarat, 380016, India.
Shah K; Department of Bioinformatics, Maharaja Krishnakumarsinhji Bhavnagar University, Bhavnagar, Gujarat, 364022, India.
Patel S; Department of Physics, Maharaja Krishnakumarsinhji Bhavnagar University, Bhavnagar, Gujarat, 364022, India.
Rawal R; Division of Medicinal Chemistry and Pharmacogenomics, Department of Cancer Biology, The Gujarat Cancer and Research Institute, NCH Campus, Asarwa, Ahmedabad, Gujarat, 380016, India.
Umrania V; Division of Medicinal Chemistry and Pharmacogenomics, Department of Cancer Biology, The Gujarat Cancer and Research Institute, NCH Campus, Asarwa, Ahmedabad, Gujarat, 380016, India.

Interdiscip Sci ; 10(3): 467-475, 2018 Sep.

Article em En | MEDLINE | ID: mdl-27896663

Assuntos

Quebra Cromossômica; Biologia Computacional/métodos; Dano ao DNA/genética; Neoplasias Hematológicas/genética; Duplicações Segmentares Genômicas; Translocação Genética; Algoritmos; Composição de Bases/genética; Humanos; Íntrons/genética; Sequências Repetitivas de Ácido Nucleico/genética

Palavras-chave

Chromosomal breakage; Chromosomal translocations; Cytogenetic abnormalities; Hematological malignancies; Physicochemical parameters; Segmental duplication; Stress-induced duplex destabilization

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Translocação Genética / Dano ao DNA / Neoplasias Hematológicas / Biologia Computacional / Quebra Cromossômica / Duplicações Segmentares Genômicas Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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