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Genome-Wide Interaction Analysis of Air Pollution Exposure and Childhood Asthma with Functional Follow-up.
Gref, Anna; Merid, Simon K; Gruzieva, Olena; Ballereau, Stéphane; Becker, Allan; Bellander, Tom; Bergström, Anna; Bossé, Yohan; Bottai, Matteo; Chan-Yeung, Moira; Fuertes, Elaine; Ierodiakonou, Despo; Jiang, Ruiwei; Joly, Stéphane; Jones, Meaghan; Kobor, Michael S; Korek, Michal; Kozyrskyj, Anita L; Kumar, Ashish; Lemonnier, Nathanaël; MacIntyre, Elaina; Ménard, Camille; Nickle, David; Obeidat, Ma'en; Pellet, Johann; Standl, Marie; Sääf, Annika; Söderhäll, Cilla; Tiesler, Carla M T; van den Berge, Maarten; Vonk, Judith M; Vora, Hita; Xu, Cheng-Jian; Antó, Josep M; Auffray, Charles; Brauer, Michael; Bousquet, Jean; Brunekreef, Bert; Gauderman, W James; Heinrich, Joachim; Kere, Juha; Koppelman, Gerard H; Postma, Dirkje; Carlsten, Christopher; Pershagen, Göran; Melén, Erik.
Afiliação
  • Gref A; 1 Institute of Environmental Medicine.
  • Merid SK; 1 Institute of Environmental Medicine.
  • Gruzieva O; 1 Institute of Environmental Medicine.
  • Ballereau S; 2 European Institute for Systems Biology and Medicine, CNRS-ENS-UCBL, Université de Lyon, Lyon, France.
  • Becker A; 3 Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.
  • Bellander T; 1 Institute of Environmental Medicine.
  • Bergström A; 4 Centre for Occupational and Environmental Medicine, Stockholm County Council, Stockholm, Sweden.
  • Bossé Y; 1 Institute of Environmental Medicine.
  • Bottai M; 4 Centre for Occupational and Environmental Medicine, Stockholm County Council, Stockholm, Sweden.
  • Chan-Yeung M; 5 Quebec Heart and Lung Institute and.
  • Fuertes E; 6 Department of Molecular Medicine, Laval University, Quebec City, Quebec, Canada.
  • Ierodiakonou D; 1 Institute of Environmental Medicine.
  • Jiang R; 7 Department of Medicine.
  • Joly S; 9 School of Population and Public Health.
  • Jones M; 8 Institute of Epidemiology I, Helmholtz Zentrum München - German Research Centre for Environmental Health, Neuherberg, Germany.
  • Kobor MS; 10 Section of Paediatrics, Department of Medicine, Imperial College London, London, United Kingdom.
  • Korek M; 11 Department of Epidemiology.
  • Kozyrskyj AL; 12 Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, and.
  • Kumar A; 2 European Institute for Systems Biology and Medicine, CNRS-ENS-UCBL, Université de Lyon, Lyon, France.
  • Lemonnier N; 12 Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, and.
  • MacIntyre E; 12 Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, and.
  • Ménard C; 1 Institute of Environmental Medicine.
  • Nickle D; 13 Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
  • Obeidat M; 1 Institute of Environmental Medicine.
  • Pellet J; 14 Department of Public Health Epidemiology, Unit of Chronic Disease Epidemiology, Swiss Tropical and Public Health Institute, University of Basel, Switzerland.
  • Standl M; 2 European Institute for Systems Biology and Medicine, CNRS-ENS-UCBL, Université de Lyon, Lyon, France.
  • Sääf A; 9 School of Population and Public Health.
  • Söderhäll C; 8 Institute of Epidemiology I, Helmholtz Zentrum München - German Research Centre for Environmental Health, Neuherberg, Germany.
  • Tiesler CMT; 15 Environmental and Occupational Health, Public Health Ontario, Toronto, Ontario, Canada.
  • van den Berge M; 2 European Institute for Systems Biology and Medicine, CNRS-ENS-UCBL, Université de Lyon, Lyon, France.
  • Vonk JM; 16 Merck & Co Inc, Rahway, New Jersey.
  • Vora H; 17 Centre for Heart Lung Innovation, University of British Columbia, Vancouver, British Columbia, Canada.
  • Xu CJ; 2 European Institute for Systems Biology and Medicine, CNRS-ENS-UCBL, Université de Lyon, Lyon, France.
  • Antó JM; 8 Institute of Epidemiology I, Helmholtz Zentrum München - German Research Centre for Environmental Health, Neuherberg, Germany.
  • Auffray C; 1 Institute of Environmental Medicine.
  • Brauer M; 18 Department of Biosciences and Nutrition.
  • Bousquet J; 19 Center for Innovative Medicine, and.
  • Brunekreef B; 20 Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
  • Gauderman WJ; 7 Department of Medicine.
  • Heinrich J; 21 Division of Metabolic Diseases and Nutritional Medicine, Ludwig-Maximilians-University of Munich, Dr. von Hauner Children's Hospital, Munich, Germany.
  • Kere J; 22 Department of Pulmonology.
  • Koppelman GH; 23 Groningen Research Institute for Asthma and COPD.
  • Postma D; 11 Department of Epidemiology.
  • Carlsten C; 23 Groningen Research Institute for Asthma and COPD.
  • Pershagen G; 24 Preventive Medicine, University of Southern California, Los Angeles, California.
  • Melén E; 22 Department of Pulmonology.
Am J Respir Crit Care Med ; 195(10): 1373-1383, 2017 05 15.
Article em En | MEDLINE | ID: mdl-27901618
RATIONALE: The evidence supporting an association between traffic-related air pollution exposure and incident childhood asthma is inconsistent and may depend on genetic factors. OBJECTIVES: To identify gene-environment interaction effects on childhood asthma using genome-wide single-nucleotide polymorphism (SNP) data and air pollution exposure. Identified loci were further analyzed at epigenetic and transcriptomic levels. METHODS: We used land use regression models to estimate individual air pollution exposure (represented by outdoor NO2 levels) at the birth address and performed a genome-wide interaction study for doctors' diagnoses of asthma up to 8 years in three European birth cohorts (n = 1,534) with look-up for interaction in two separate North American cohorts, CHS (Children's Health Study) and CAPPS/SAGE (Canadian Asthma Primary Prevention Study/Study of Asthma, Genetics and Environment) (n = 1,602 and 186 subjects, respectively). We assessed expression quantitative trait locus effects in human lung specimens and blood, as well as associations among air pollution exposure, methylation, and transcriptomic patterns. MEASUREMENTS AND MAIN RESULTS: In the European cohorts, 186 SNPs had an interaction P < 1 × 10-4 and a look-up evaluation of these disclosed 8 SNPs in 4 loci, with an interaction P < 0.05 in the large CHS study, but not in CAPPS/SAGE. Three SNPs within adenylate cyclase 2 (ADCY2) showed the same direction of the interaction effect and were found to influence ADCY2 gene expression in peripheral blood (P = 4.50 × 10-4). One other SNP with P < 0.05 for interaction in CHS, rs686237, strongly influenced UDP-Gal:betaGlcNAc ß-1,4-galactosyltransferase, polypeptide 5 (B4GALT5) expression in lung tissue (P = 1.18 × 10-17). Air pollution exposure was associated with differential discs, large homolog 2 (DLG2) methylation and expression. CONCLUSIONS: Our results indicated that gene-environment interactions are important for asthma development and provided supportive evidence for interaction with air pollution for ADCY2, B4GALT5, and DLG2.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Asma / Emissões de Veículos / Poluição do Ar / Interação Gene-Ambiente Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Asma / Emissões de Veículos / Poluição do Ar / Interação Gene-Ambiente Idioma: En Ano de publicação: 2017 Tipo de documento: Article