Modern Approaches to Studies of New Osteogenic Biomaterials on the Model of Regeneration of Critical-Size Cranial Defects in Rats.
Bull Exp Biol Med
; 162(2): 273-276, 2016 12.
Article
em En
| MEDLINE
| ID: mdl-27905031
ABSTRACT
Osteoinductive characteristics of new osteoplastic materials based on demineralized bone matrix of xenogenic origin with high and controlled degree of purification were studied on the model of regeneration of critical-size cranial defects in rats using modern approaches, including histological analysis, evaluation of morphological parameters of the bone tissue obtained by micro-computed tomography, and estimation of bone tissue growth rate using in vivo fluorochrome label. Demineralized bone matrix and, to a much greater extent, its activated form containing modified recombinant growth factor rhBMP-2 with high content of the dimeric form exhibited osteoinductive activity.
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Base de dados:
MEDLINE
Assunto principal:
Osteogênese
/
Crânio
/
Regeneração Óssea
/
Técnica de Desmineralização Óssea
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Alicerces Teciduais
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Proteína Morfogenética Óssea 2
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article