Regulation of the phosphatase PP2B by protein-protein interactions.
Biochem Soc Trans
; 44(5): 1313-1319, 2016 10 15.
Article
em En
| MEDLINE
| ID: mdl-27911714
ABSTRACT
Protein dephosphorylation is important for regulating cellular signaling in a variety of contexts. Protein phosphatase-2B (PP2B), or calcineurin, is a widely expressed serine/threonine phosphatase that acts on a large cross section of potential protein substrates when activated by increased levels of intracellular calcium in concert with calmodulin. PxIxIT and LxVP targeting motifs are important for maintaining specificity in response to elevated calcium. In the present study, we describe the mechanism of PP2B activation, discuss its targeting by conserved binding motifs and review recent advances in the understanding of an A-kinase anchoring protein 79/PP2B/protein kinase A complex's role in synaptic long-term depression. Finally, we discuss potential for targeting PP2B anchoring motifs for therapeutic benefit.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas Quinases Dependentes de AMP Cíclico
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Calcineurina
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Depressão Sináptica de Longo Prazo
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Proteínas de Ancoragem à Quinase A
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article