SHANK3 Deficiency Impairs Heat Hyperalgesia and TRPV1 Signaling in Primary Sensory Neurons.

Han, Qingjian; Kim, Yong Ho; Wang, Xiaoming; Liu, Di; Zhang, Zhi-Jun; Bey, Alexandra L; Lay, Mark; Chang, Wonseok; Berta, Temugin; Zhang, Yan; Jiang, Yong-Hui; Ji, Ru-Rong

Han, Qingjian; Kim, Yong Ho; Wang, Xiaoming; Liu, Di; Zhang, Zhi-Jun; Bey, Alexandra L; Lay, Mark; Chang, Wonseok; Berta, Temugin; Zhang, Yan; Jiang, Yong-Hui; Ji, Ru-Rong.

Afiliação

Han Q; Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA.
Kim YH; Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA.
Wang X; Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA.
Liu D; Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA.
Zhang ZJ; Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA.
Bey AL; Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA.
Lay M; Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA.
Chang W; Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA.
Berta T; Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA.
Zhang Y; Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA.
Jiang YH; Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA; Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: yong-hui.jiang@dm.duke.edu.
Ji RR; Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA; Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: ru-rong.ji@duke.edu.

Neuron ; 92(6): 1279-1293, 2016 Dec 21.

Article em En | MEDLINE | ID: mdl-27916453

Assuntos

Hiperalgesia/genética; Proteínas do Tecido Nervoso/genética; Dor/genética; Terminações Pré-Sinápticas/metabolismo; Células Receptoras Sensoriais/metabolismo; Canais de Cátion TRPV/metabolismo; Animais; Comportamento Animal; Western Blotting; Capsaicina/toxicidade; Gânglios Espinais/citologia; Humanos; Hiperalgesia/metabolismo; Imuno-Histoquímica; Inflamação/genética; Inflamação/metabolismo; Camundongos; Camundongos Knockout; Proteínas dos Microfilamentos; Canal de Sódio Disparado por Voltagem NAV1.8/metabolismo; Proteínas do Tecido Nervoso/metabolismo; Neuralgia/genética; Neuralgia/metabolismo; Dor/induzido quimicamente; Dor/metabolismo; Técnicas de Patch-Clamp; Reação em Cadeia da Polimerase Via Transcriptase Reversa; Fármacos do Sistema Sensorial/toxicidade; Medula Espinal/citologia

Palavras-chave

ASD; DRG; SHANK3; TRPV1; autism spectrum disorders; capsaicin; dorsal root ganglion; heat hyperalgesia; human sensory neurons; mice; primary sensory neurons; spinal cord dorsal horn

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dor / Células Receptoras Sensoriais / Terminações Pré-Sinápticas / Canais de Cátion TRPV / Hiperalgesia / Proteínas do Tecido Nervoso Idioma: En Ano de publicação: 2016 Tipo de documento: Article

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