Matrilin-2 regulates proliferation, apoptosis and cell cycle during radiation-induced injury in HPAEpiC cell.
Biochem Biophys Res Commun
; 485(3): 577-583, 2017 04 08.
Article
em En
| MEDLINE
| ID: mdl-27923659
ABSTRACT
Radiation pulmonary injury is related to the accumulation of extracellular matrix proteins in the alveolar interstitial space. Matrilin-2 as a component of extracellular filamentous networks, present higher level in the lung tissue from irradiated mice and irradiated pulmonary epithelial cell line, HPAEpiC cells. Knockdown of endogenous matrilin-2 prevents the apoptosis of HPAEpiC cell induced by the irradiation injury. Consistently, over-expression of matrilin-2 reduced the proliferation and induced apoptosis of HPAEpiC cells. Matrilin-2 promotes the expression of p21 via increasing the transcriptional activity of p53, by which induces the G1 phase arresting in HPAEpiC cells. In summary, matrilin-2, increased by irradiation, reduced the proliferation and induces apoptosis of pulmonary epithelial cells via p53/p21 pathway.
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MEDLINE
Assunto principal:
Apoptose
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Proliferação de Células
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Células Epiteliais
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Pontos de Checagem da Fase G1 do Ciclo Celular
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Proteínas Matrilinas
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article