Risk of preterm birth among women using drugs during pregnancy with elevated α-fetoprotein.
J Perinatol
; 37(3): 220-225, 2017 03.
Article
em En
| MEDLINE
| ID: mdl-27929528
ABSTRACT
OBJECTIVE:
Examine the risk of preterm birth (PTB) among women who use drugs during pregnancy and have elevated α-fetoprotein (AFP). STUDYDESIGN:
The sample included California singleton live births in 2005 to 2010 contained within a hospital discharge database linked to the Prenatal Screening Program. A selection of mothers who did not use drugs was selected at a ratio of 41. Risk of PTB was calculated using adjusted odds ratios and 95% confidence intervals (CIs) for women who did or did not use drugs by their AFP percentile.RESULTS:
We identified 7190 women who used drugs and selected 28 760 women who did not. Of women using cocaine with AFP ⩾95th percentile, 43.8% delivered prematurely. Women using drugs with AFP ⩾95th percentile were 11 to 35 times as likely to deliver <32 weeks.CONCLUSION:
The combination of drug use and elevated AFP results in high rates of PTB. This combination results in an additive risk.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Diagnóstico Pré-Natal
/
Alfa-Fetoproteínas
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Transtornos Relacionados ao Uso de Substâncias
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Nascimento Prematuro
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article