Time-saving screening for diabetes in patients with coronary artery disease: a report from EUROASPIRE IV.
BMJ Open
; 6(12): e013835, 2016 12 08.
Article
em En
| MEDLINE
| ID: mdl-27932342
ABSTRACT
BACKGROUND:
WHO advocates 2-hour oral glucose tolerance test (OGTT) for detecting diabetes mellitus (DM). OGTT is the most sensitive method to detect DM in patients with coronary artery disease (CAD). Considered time consuming, the use of OGTT is unsatisfactory. A 1-hour plasma glucose (1hPG) test has not been evaluated as an alternative in patients with CAD.OBJECTIVES:
To create an algorithm based on glycated haemoglobin (HbA1c), fasting plasma glucose (FPG) and 1hPG limiting the need of a 2-hour plasma glucose (2hPG) in patients with CAD.METHODS:
951 patients with CAD without DM underwent OGTT. A 2hPG≥11.1â mmol/L was the reference for undiagnosed DM. The yield of HbA1c, FPG and 1hPG was compared with that of 2hPG.RESULTS:
Mean FPG was 6.2±0.9â mmol/L, and mean HbA1c 5.8±0.4%. Based on 2hPG≥11.1â mmol/L 122 patients (13%) had DM. There was no value for the combination of HbA1c and FPG to rule out or in DM (HbA1c≥6.5%; FPG≥7.0â mmol/L). In receiver operating characteristic analysis a 1hPG≥12â mmol/L balanced sensitivity and specificity for detecting DM (both=82%; positive and negative predictive values 40% and 97%). A combination of FPG<6.5â mmol/L and 1hPG<11â mmol/L excluded 99% of DM. A combination of FPG>8.0â mmol/L and 1hPG>15â mmol/L identified 100% of patients with DM.CONCLUSIONS:
Based on its satisfactory accuracy to detect DM an algorithm is proposed for screening for DM in patients with CAD decreasing the need for a 2-hour OGTT by 71%.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Glicemia
/
Algoritmos
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Doença da Artéria Coronariana
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Hemoglobinas Glicadas
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Programas de Rastreamento
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Diabetes Mellitus
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Teste de Tolerância a Glucose
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article