Necrotizing Enterocolitis and Growth in Preterm Infants Fed Predominantly Maternal Milk, Pasteurized Donor Milk, or Preterm Formula: A Retrospective Study.
Am J Perinatol
; 34(7): 676-683, 2017 06.
Article
em En
| MEDLINE
| ID: mdl-27936476
ABSTRACT
Objective To evaluate the association between necrotizing enterocolitis (NEC), growth, and feeding. Methods This is a retrospective study of 551 infants (birth weight ≤ 1,500 g, ≤32 weeks' gestation). NEC, Bell's stage ≥ 2, was confirmed by independent review of sentinel radiographs. Feeding type was defined as ≥ 50% maternal milk (MM), pasteurized donor human milk (PDHM), or preterm formula (PF). Demographic and clinical characteristics including growth were compared between the three groups. Multivariable regression analysis was performed to control variables that differed in bivariate analysis. Results PDHM and PF mothers were more likely to be African-American, be enrolled in Medicaid, and have chorioamnionitis. PF mothers received antenatal steroids less frequently. NEC rates were different by feeding group (MM 5.3%; PHDM 4.3%; PF 11.4%; p = 0.04). Adjusting for group differences, lower gestational age (adjusted odds ratio [aOR] 0.85; 95% confidence interval [CI] 0.74-0.97; p = 0.02], and PF (aOR 2.53; 95% CI 1.15-5.53; p = 0.02] were associated with NEC. There were no differences in other health outcomes or growth at hospital discharge. Conclusion MM and PDHM feedings, given until 34 weeks postmenstrual age, were associated with lower rates of NEC in very low birth weight infants without interfering with growth.
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Base de dados:
MEDLINE
Assunto principal:
Recém-Nascido Prematuro
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Nutrição Parenteral
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Recém-Nascido de muito Baixo Peso
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Enterocolite Necrosante
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Fenômenos Fisiológicos da Nutrição do Lactente
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article